Expert opinion on detecting and treating depression in palliative care: A Delphi study
© Rayner et al; licensee BioMed Central Ltd. 2011
Received: 15 December 2010
Accepted: 27 May 2011
Published: 27 May 2011
There is a dearth of data regarding the optimal method of detecting and treating depression in palliative care. This study applied the Delphi method to evaluate expert opinion on choice of screening tool, choice of antidepressant and choice of psychological therapy. The aim was to inform the development of best practice recommendations for the European Palliative Care Research Collaborative clinical practice guideline on managing depression in palliative care.
18 members of an international, multi-professional expert group completed a structured questionnaire in two rounds, rating their agreement with proposed items on a scale from 0-10 and annotating with additional comments. The median and range were calculated to give a statistical average of the experts' ratings.
There was contention regarding the benefits of screening, with 'routine informal asking' (median 8.5 (0-10)) rated more highly than formal screening tools such as the Hospital Anxiety and Depression Scale (median 7.0 (1-10). Mirtazapine (median 9 (7-10) and citalopram (median 9 (5-10) were the considered the best choice of antidepressant and cognitive behavioural therapy (median 9.0 (3-10) the best choice of psychological therapy.
The range of expert ratings was broad, indicating discordance in the views of experts. Direct comparative data from randomised controlled trials are needed to strengthen the evidence-base and achieve clarity on how best to detect and treat depression in this setting.
The management of depression in palliative care is complicated by the physical and psychosocial effects of advanced disease. The somatic symptoms of depression (e.g. fatigue, insomnia and poor appetite) mimic those of advanced illness, making it difficult to determine whether such symptoms are due to depression or physical disease . Moreover, in palliative care it is difficult to differentiate depression from understandable fear and distress relating to declining health and impending death . Antidepressant drugs and psychological therapies are the most common treatments for depression, yet there is limited evidence for their efficacy in palliative populations [3–5]. Further, studies suggest that in palliative care depression frequently goes untreated , and that interventions are often initiated so late that patients die before they have time to take effect .
The European Palliative Care Research Collaborative (EPCRC) recently produced a clinical guideline for the management of depression in palliative care to improve care for this population . The purpose of the guideline is to provide recommendations on preventing, detecting and treating depression in palliative care, in order to aid decision-making, establish clinical policy and improve patient outcomes. Recommendations were devised using the best available evidence. Where evidence was equivocal or absent, expert opinion was sought. At the beginning of the project, an expert group was constituted to identify clinical priorities and offer knowledge, experience and opinion on contentious aspects of clinical practice. Literature scoping and initial discussions with the expert group revealed two main areas of uncertainty:
1) Choice of screening tool
Detection of depression in palliative care is bedevilled by a plethora of tools and a paucity of evidence . Though few studies have shown screening to impact upon patient outcomes , it is advocated nonetheless as a simple, systematic and cost-effective way of improving identification of depression in medical settings . To be useful to clinicians, screening tools must balance validity of assessment against brevity. Many tools were developed for use in physically healthy people and their applicability to palliative care is questionable . The multitude of screening tools used in clinical practice and research attests to the current confusion surrounding the optimal method of detecting depression in palliative care .
2) Choice of treatment
Screening should always be complemented by effective treatment and a comprehensive management strategy [14, 15]. Antidepressants have been shown to be efficacious and acceptable for treating depression in patients with life-threatening illness . However, there is insufficient direct comparative data to recommend one antidepressant over others. Choosing an antidepressant for palliative care patients with multiple symptoms and medications is particularly challenging because of the increased risk of drug interactions and contraindications. Psychological therapy is the other recommended treatment for depression , but there are questions surrounding its feasibility and acceptability in palliative care. A recent Cochrane review found that psychotherapy was effective in treating depressive states in patients with advanced cancer . However, there were not enough trials to draw conclusions regarding the relative efficacy of different types of therapy.
As there was insufficient evidence in the literature to guide choice of screening tool and choice of treatment, we conducted a Delphi study to evaluate expert opinion and inform the EPCRC guideline recommendations.
The following research questions were posed:
1) Which screening tool is most useful for detecting depression in palliative care?
2) Which antidepressant is most appropriate for treating depression in palliative care?
3) Which psychological therapy is most appropriate for treating depression in palliative care?
We used the Delphi method to assess expert opinion on screening for and treating depression in palliative care. Delphi is a formal consensus technique used to obtain and evaluate the views of an expert group with knowledge and experience in a specialised area. It has been found to be an effective method for determining the level of expert consensus on clinical questions and it is increasingly used in research . Correspondence is carried out by email, making Delphi a feasible method for achieving consensus in a multinational expert group. Moreover, this allows anonymity and prevents prominent members of the group from exerting undue influence. Delphi is an iterative process involving repeated expert input and statistical description of responses. The aim is to elicit experts' views and encourage converging opinion on uncertain or contentious issues.
Background of the expert group
Present work setting
Clinical practice in palliative care
Research in palliative care
CBT in physical illness
Old age psychiatry
Items relating to choice of screening tool, choice of antidepressant and choice of psychological therapy were included in a structured questionnaire (see Additional file 1). These topics were chosen in consultation with the Expert Group. A list of key clinical questions was drafted by the EPCRC guideline development group (LR, MH, AP, IHJJ) based on the existing literature and emailed to the Expert Group who commented on its scope and relevance. The list was refined and experts were asked to rate the clinical importance of included items. The questions included in the Delphi questionnaire were those rated most highly by the expert group.
The Delphi method was applied in two rounds. In the first round, the questionnaire was emailed to the expert group with a request for members to rate their level of agreement with each item on a scale from 0 to 10. The experts were invited to leave comments to annotate their ratings and to suggest additional items to be included in the second round. In the second round the median and range of ratings were reported to the group together with anonymised comments. Items suggested by experts in the first round were added to the Delphi questionnaire, which the expert group was requested to complete again in light of the results of the first round. The median and range reported below are from the second round of Delphi as this represents the final view of the expert group.
Eighteen of the 29 experts (62%) returned a questionnaire in one or both rounds of the Delphi exercise. Respondents included seven palliative care physicians, six psychiatrists (all with experience working in palliative care), two psycho-oncologists, a behavioural psychotherapist, a clinical psychologist and a general practitioner.
Experts' ratings: Method of detection
0 = not useful, 10 = very useful
Routine informal asking*
Round 2: Median 8.5 (0-10); n = 10
-It is entirely appropriate to ask patients about their mood as part of a comprehensive symptom assessment
Two-items (low mood & loss of interest)
Round 1: Median 8.0 (4-10); n = 13
Round 2: Median 7.0 (2-9); n = 13
-Too rigid, it seems the shortest summary of a long screening questionnaire
-There is evidence to support this
-We are talking about screening, not assessment: if patient presents with a symptom then full assessment, but if screening otherwise mentally well population then this is a useful tool
Hospital Anxiety and Depression Scale
Round 1: Median 7.0 (1-10); n = 13
Round 2: Median 7.0 (1-10); n = 13
-Long to complete for palliative care patients
-Have used it in palliative care patients very successfully
-I don't find this difficult to use in palliative care in hospice or hospital setting, even for pretty weary patients
-Is just a screener for emotional distress, not useful in diagnosing depression
-Very useful, very acceptable, very under-rated. For some reason the palliative care community have got it in for the HADS, but I don't think there is any evidence that any other measure is better, and quite a few are a lot worse
-Less clear distinction between depression and anxiety
Single-item "Are you depressed?"
Round 1: Median 5.0 (0-10); n = 13
Round 2: Median 7.0 (0-10); n = 12
-I know the limitations, but in my experience helpful in daily practice
-Not really specific
-Too direct and one closed question is not enough screening
-Chochinov's first paper was based on a false premise. It does sort of work, though, but pretty non-discriminating
As part of generic symptom assessment (e.g. POS, ESAS)
Round 1: Median 7.0 (2-10); n = 13
Round 2: Median 6.5 (1-10); n = 14
-Good just as first wide screening, utilizes open questions within a conversation about many other symptoms, hence less fear ... less defence in answer, nevertheless not enough for a full screening
-These aren't at all bad
-Screening by definition has to be simple and quick. Don't confuse screening with severity assessment, there needs to be a 2 stage process: 1) screen; 2) if patient screens positive then use a tool to assess severity
Brief Edinburgh Depression Scale (BEDS)
Round 1: Median 8.0 (2-10); n = 9
Round 2: Median 5.0 (1-9); n = 12
-Easy to use
-The simplified version; but the 6 sentences are too crude for our patients
Beck's Depression Inventory*
Round 2: Median 5.0 (0-8); n = 12
-Largely about thinking style and content and thus relatively un-skewed by physical problems. A better scale for measuring progress than HADS
-Better use only for assessment
-After screening, if practitioner is experienced and confident to use, but this is really for specialist psychiatric services
Round 1: Median 5.0 (0-10); n = 11
Round 2: Median 3.0 (0-9); n = 11
-It's a diagnostic tool, but it's pretty acceptable and not very difficult to use
- It's a severity tool, it is easy to use, primary care practitioners will be familiar with this
Distress Thermometer (DT)
Round 1: Median 6.0 (0-8); n = 9
Round 2: Median 2.0 (0-10); n = 13
-Distress and depression are different
-Useful screen for generalists to decide whether to refer for specialist help
-Useful to integrate depression in routine screening of other symptoms, mixed with distress, hence perceived by patients not as psychiatric inquiry.
Experts' ratings: Choice of antidepressant
0 = not useful, 10 = very useful
Round 1: Median 9.0 (7-10); n = 11
Round 2: Median 9.0 (7-10); n = 11
-Some data, good profile regarding side effects, at this time most used
-Seems well tolerated
-When side effects on sleep and appetite are handy
-Has useful sedative properties and well tolerated
-My first-line - evidence is that it is more effective than SSRIs and appetite stimulant and sedative qualities are useful side effects
Round 1: Median 9.0 (5-10); n = 11
Round 2: Median 9.0 (5-10); n = 13
-Side effects due to its antIHJJistaminic action
Round 1: Median 7.5 (0-10); n = 8
Round 2: Median 8.0 (0-9); n = 13
-Less side effects than tricyclics
-Useful if patient needs help for sedation
-If depression is associated with chronic high level of anxiety
-Not straightforward - discontinuation symptoms common. Cardiac toxicity
Round 1: Median 7.0 (2-10); n = 11
Round 2: Median 7.5 (0-10); n = 12
-Favourable side effect profile
-Interaction with dopamine system could give different and more side effects than other SSRIs
-Least adverse effects, presently best available
Round 1: Median 8.0 (0-10); n = 10
Round 2: Median 7.0 (0-10); n = 13
-Not cost effective alternative to citalopram
-Better tolerated than R-citalopram and less interaction with cytocrome 450 2D6
Round 1: Median 5.0 (1-9); n = 10
Round 2: Median 4.0 (0-8); n = 12
-Too sedative, effect too delayed, frequent compliance obstacle due to side effects
-If indicated for neuropathic pain
-For individual TCAs I don't think there is sufficient evidence to differentially rate, although clinically I would favour those drugs that are used most often in palliative care anyway e.g. amitriptyline
-An excellent antidepressant
Round 1: Median 5.5 (0-9); n = 10
Round 2: Median 3.0 (0-7); n = 13
-Too many pharmacological interactions
-Interactions and withdrawal problems
-No place - withdrawal syndrome
Round 1: Median 3.0 (0-6); n = 10
Round 2: Median 3.0 (0-6); n = 13
-Too long half time, not useful for physically ill people
-Long t1/2 and interactions
-Too disinhibitory, but not better antidepressant than other SSRIs
Round 1: Median 5.0 (0-6); n = 7
Round 2: Median 2.0 (0-8); n = 11
-Just in patients with depressive history who have already utilized before
Round 1: Median 2.0 (0-9); n = 9
Round 2: Median 2.0 (0-7); n = 11
-If indicated for neuropathic pain
-Less than amitriptyline
Round 1: Median 5.0 (0-9); n = 7
Round 2: Median 0.0 (0-7); n = 11
-Little used in practice compared with other drugs and little evidence available
-No point really - it is pharmacologically similar to mirtazapine, which doesn't hit the white cells
Though no TCA scored highly in the Delphi study, amitriptyline achieved the highest median score (median 5.0, range (1-9) probably on account of its efficacy in alleviating neuropathic pain:; "...clinically I would favour those drugs that are used most often in palliative care anyway e.g. amitriptyline"; "If indicated for neuropathic pain". The least favoured SSRIs were fluoxetine (median 3.0, range 0-6): "Too long half-life, not useful for physically ill people", and paroxetine (median 5.5, range 0-9): "Interactions and withdrawal problems". Of all the antidepressants, mianserin was rated most poorly: "No point really - it is pharmacologically similar to mirtazapine, which doesn't hit the white blood cells".
Experts' ratings: Choice of psychological therapy
0 = not useful, 10 = very useful
Cognitive Behavioural Therapy (CBT)
Round 1: Median 9.5 (4-10); n = 12
Round 2: Median 9.0 (3-10); n = 12
-Choice depends on therapist's expertise and patient's preference!!
-Although psychotherapy at the end of life has some evidence base, there is less evidence for the effectiveness of individual therapies, so I feel unable to rate.
-Is there any evidence anywhere that any of the below are effective interventions, and do no harm. Too much unproven 'counselling' has caused harm over decades that I would not want my patients and their carers exposed to this
Round 1: Median 10.0 (1-10); n = 11
Round 2: Median 8.0 (3-10); n = 12
-Probably better chance than CBT
Presence of spiritual assistant upon request*
Round 2: Median 7.5 (1-10); n = 9
-We have to get better at specifically enquiring about the presence of a spiritual dimension to distress
-Not for all patients - just on request
Round 1: Median 7.0 (0-10); n = 9
Round 2: Median 7.0 (0-10); n = 10
-Useful for those who can learn it: interestingly, 'living in the moment' is a strategy spontaneously adopted by many patients who are coping well under difficult circumstances
-Not sure if there's any evidence
Round 1: Median 6.0 (1-10); n = 11
Round 2: Median 7.0 (3-9); n = 9
-Temporarily relieves symptoms - but empowering and engenders hope
-Sometimes impossible for cultural or age resistance
Round 1: Median 5.0 (0-8); n = 9
Round 2: Median 7.0 (0-9); n = 9
-I have experience: running well, easily accepted - especially by aged people - empowers the patient and increases his/her communication with loved ones
-Not sure if there's any evidence
Round 2: Median 6.0 (0-8); n = 9
-For those who cannot be reached by words
-More evidence for relief of physical symptoms than depression
Round 1: Median 5.5 (0-10); n = 10
Round 2: Median 5.0 (0-8); n = 10
-Probably too time-consuming
Round 1: Median 5.0 (1-8); n = 12
Round 2: Median 4.0 (0-8); n = 11
-Can be very useful
-Useful just if the family is reduced to two relevant people
Overall, fewer experts responded to the psychological therapy question, possibly on account of the expert group including fewer psychologists than psychiatrists. The lower response to this question may also indicate difficulty rating items in the absence of evidence: "Although psychotherapy at the end of life has some evidence base, there is less evidence for the effectiveness of individual therapies, so I feel unable to rate".
A single question assessing depression  and two questions assessing low mood and loss of interest  were rated as moderately useful by the expert group (median 7.0). However, studies have shown that whilst these items are effective at excluding depression in the non-depressed, they are less successful at confirming cases , and this was reflected in the experts' comments. Nevertheless, some clinicians valued these 'ultra-short' screening tools: "I know the limitations, but in my experience helpful in daily practice". Of the longer screening tools, the HADS was rated most highly (median 7). Though one expert felt that the HADS was too long for palliative patients, a number commented that they had used it successfully in this setting.
Our initial objective was to determine the optimal screening tool for detecting depression in palliative care, yet perhaps the most important finding was that the experts rated 'informal routine asking' as more useful than administering a specified screening tool. Clinicians and patients may feel more relaxed and open if mood is considered in the context of a general conversation about symptoms, coping and well-being. This 'holistic' approach allows patients to tell their story and emphasise the issues important to them . It is possible that a more rigid 'tick-box' approach may detract from deeper engagement with patients' problems.
Screening for depression has been recommended by several influential bodies [11, 26]. However, research on screening has focused on tool development and validation [27, 28], and the less easily evaluated yet fundamental question of whether screening improves patient outcomes remains unanswered . We know of no randomised controlled trials assessing the impact of screening in palliative care, though there is nothing to suggest that its effects would be different from that found in other patient groups. A meta-analysis by Gilbody et al showed that introduction of depression screening in non-mental health settings was associated with a modest increase in the detection of depression (RR 1.27 (CI 1.02-1.59)), but had no effect on depression outcomes (Standardised mean difference -0.02 (CI -0.25-0.20)) . However, this review only included studies that evaluated screening alone without further enhancement of care (e.g. case managers, nursing interventions, collaborative care). Identifying distress is just one link in a chain of actions needed to optimally manage depression. Improving patient outcomes requires a comprehensive system of care that addresses each link: detection, diagnosis, assessment, appropriate referral and effective intervention. Whilst screening for depression is useful as a catalyst to consider subsequent action, its intrinsic value is unclear. We assessed experts' preferred methods of detecting and treating depression in palliative care, but we did not address the decisions and actions required after detection to instigate appropriate and effective intervention. Future studies would benefit from a qualitative component exploring if and how positive screening outcomes influence treatment decisions and patient care. Further, data on the proportion of potential cases followed up with a diagnostic interview could elucidate the apparent gap between screening and subsequent benefit for the patient.
Of the eleven antidepressants rated by the expert group, five achieved a median rating of 7 or higher, whilst six were rated 4 or lower. This shows a clear distinction between the antidepressants considered to be a good choice for treating depression in palliative care (mirtazapine, citalopram, venlafaxine, sertraline, escitalopram), and those considered less appropriate (amitriptyline, paroxetine, fluoxetine, imipramine, nortriptyline, mianserin). Whilst there was some consensus about choice of antidepressant, this should not be mistaken for clear evidence that one treatment is more effective than others. Such evidence can only be achieved from a randomised controlled trial, and evidence from the Delphi exercise is by comparison weak. However, with the exception of citalopram, the antidepressants rated highly by the expert group matched those found to be most efficacious in Cipriani's recent meta-analysis comparing 12 new-generation antidepressants. Of the four drugs identified as most efficacious in this meta-analysis, sertraline and escitalopram were better tolerated than mirtazapine and venlafaxine . The extent to which Cipriani's findings from trials in physically well people can be extrapolated to patients receiving palliative care is open to debate. In palliative care, the coexistence and interaction of multiple symptoms and treatments complicates choice of antidepressant. The side effects of specific antidepressants may alleviate or exacerbate different symptoms of advanced disease. For example, tricyclic antidepressants can relieve neuropathic pain , but are generally contraindicated for patients with heart disease or liver failure . The side effects of mirtazapine include sedation and weight gain , which are undesirable for most physically well people, but benefit many palliative care patients, particularly those with loss of appetite, a major concern for many patients and their families.
In addition to the present Delphi study, the authors have conducted a meta-analysis of antidepressants for depression in physical illness  and reported a more detailed analysis of those studies which examined depression in life-threatening illness . Our review showed that antidepressants were more effective than placebo in treating depression in this context. There were not enough trials to enable us to assess the efficacy and acceptability of specific antidepressants, but we did conduct a subgroup analysis comparing classes of antidepressant. All the studies compared individual antidepressants with placebo and did not make direct comparisons between different antidepressants, therefore it is difficult to draw conclusions on the relative tolerability and effectiveness of classes of antidepressants, Nevertheless, indirect comparison suggested that in these populations there were no obvious differences between SSRIs and tricyclics in terms of drop out from treatment, and the TCAs were possibly more effective. The combined effect size for the three trials using mianserin or mirtazapine exceeded that observed for both SSRIs and TCAs. This gives some indirect credence to the expert group's high rating of mirtazapine, though comparative trials are needed before conclusions can be drawn.
In line with current NICE guidance [11, 34], the expert group rated CBT as the most useful psychological therapy for depression in palliative care. Though there is good evidence for CBT in people without physical illness, there is a paucity of data in palliative care [35, 36]. A systematic review by Coventry et al identified two RCTs showing CBT to reduce depressive symptoms in COPD patients , and a recent cluster randomised trial showed that training palliative care nurses in CBT reduced patients' anxiety, but no significant effect was found for depression . For problem-solving therapy studies are scarcer still, though its simplicity and brevity make it a popular choice in palliative care - as reflected in the experts' ratings. The item "Presence of spiritual assistant upon request" was suggested by an expert in the first round of Delphi, and then attained the third highest rating in the second round. Life-threatening illness poses existential challenges that can exacerbate distress at the end of life and surveys have indicated that around one third of cancer patients have unmet spiritual needs [38, 39]. The expert group's endorsement of spiritual assistance as a useful intervention in palliative care is corroborated by a recent survey showing an association between spiritual care and better quality life near death . However, the efficacy of spiritual care in specifically improving depression outcomes has not been determined, and nor is it likely that such an approach will be testable in a conventional RCT. Rather than see spiritual care as competing with conventional psychotherapies, it might be better conceptualised as an adjunct for those patients who wish to have it. Mindfulness-based therapy, guided imagery and narrative therapy were rated as moderately useful by the expert group (median 7) despite a lack of evidence in palliative care. Randomised controlled trials of these therapies are needed to provide an evidence base to support expert opinion.
Strengths and limitations
Although modest, our 62% response rate is similar to that achieved in previous studies in which the Delphi method has been applied in palliative care research [17, 41]. Several reminder emails were sent to the expert group as a whole, but we felt that pursuing non-responders individually would detract from the anonymity of the Delphi process.
The multinational nature of the expert group enabled the Delphi study to capture the views of experts from ten European countries. However, development of the guideline was led by a UK research group and there was a British bias in the composition of the expert group. As a consequence our findings may be more representative of the views of UK health care professionals, and less applicable to other European countries. The expert group was multidisciplinary to encompass the perspectives of the different professions involved in the management of depression in palliative care. Despite this, we acknowledge that certain disciplines, such as psychology and nursing may have been under-represented .
Previous studies have demonstrated the potential for the Delphi process to increase expert consensus (indicated by a reduction in the range of ratings from round to round). In this study the spread of expert responses tended to remain broad in both rounds, indicating entrenched differences in palliative care providers' views on how best to detect and treat depression. However, experts' ratings of the appropriateness of different antidepressants in palliative care indicated some convergence in opinion between round one and two. In round two there was an even sharper distinction between those antidepressants deemed appropriate in palliative care and those not (see Table 3). With the exception of escitalopram, the favoured antidepressants achieved an equal or higher median rating in round two compared to round one, whereas the antidepressants considered less appropriate, achieved an equal or lower median rating in the second round. Thus, the Delphi process contributed to a clearer picture of experts' opinion on choice of antidepressant. In relation to choice of screening tool and choice of psychological therapy, there was less evidence of convergence in expert opinion between round one and two. However our aim was to evaluate experts' views and assess the level of expert agreement, not to achieve consensus on clinical practice. The range of ratings in this study reveals wide variation in expert opinion, which is underscored by the contrasting comments clinicians left to annotate their scores. Our sample of experts was not sufficiently large to enable investigation of systematic differences in opinion based on characteristics such as clinical specialty, country or age. This could be a fruitful avenue for future research.
The Delphi method is an efficient and effective way of eliciting expert opinion and promoting international collaboration. Experts with knowledge and experience of managing depression in palliative care were unconvinced about the benefits of screening and prefer to 'ask' patients about mood as part of routine symptom assessment. Mirtazapine and citalopram were the considered the best choice of antidepressant and cognitive behavioural therapy the best choice of psychological therapy. The range of expert ratings was broad, indicating discordance in the views of experts. There was little evidence of convergence of opinion in round two. The EPCRC depression guideline aims to prevent inappropriate variation in patient care by providing best practice recommendations on managing depression in palliative care. However, a paucity of high quality evidence precludes definitive statements regarding the optimal screening tool, antidepressant and psychological therapy. Direct comparative data are needed to strengthen the evidence-base and achieve clarity on how best to detect and treat depression in this setting.
This work was performed on behalf of the European Palliative Care Research Collaborative. The European Palliative Care Research Collaborative is funded by the European Commission's Sixth Framework Programme (contract no LSHC-CT-2006-037777, EPCRC) with the overall aim to improve treatment of pain, depression and fatigue through translation research. Core scientific group/work package leaders: Stein Kaasa (project coordinator), Frank Skorpen, Marianne Jensen Hjermstad, and Jon Håvard Loge, Norwegian University of Science and Technology (NTNU); Geoffrey Hanks, University of Bristol; Augusto Caraceni and Franco De Conno, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; Irene J Higginson, King's College London; Florian Strasser, Cantonal Hospital St. Gallen; Lukas Radbruch, RWTH Aachen University; Kenneth Fearon, University of Edinburgh; Hellmut Samonigg, Medical University of Graz; Ketil Bø, Trollhetta AS, Norway; Irene Rech-Weichselbraun, Bender MedSystems GmbH, Austria; Odd Erik Gundersen, Verdande Technology AS, Norway. Scientific advisory group: Neil Aaronson, The Netherlands Cancer Institute; Vickie Baracos and Robin Fainsinger, University of Alberta; Patrick C. Stone, St. George's University of London; Mari Lloyd Williams, University of Liverpool. Project management: Stein Kaasa, Ola Dale, and Dagny F. Haugen, NTNU.
LR is supported by the European Commission's Sixth Framework Programme (contract no LSHC-CT-2006-037777). AP is supported by St Christopher's Hospice, London. IJH & MH are Principal Investigators for the COMPASS collaborative (the UK National Cancer Research Institute Supportive and Palliative Care Research Collaborative), and are both NIHJJR Senior Investigators. MH is supported by the NIHJJR Biomedical Research Centre for Mental Health at the South London and Maudsley NHS Foundation Trust and Institute of Psychiatry, King's College London.
We thank Marjolein Bannink, Stephen Barclay, Augusto Caraceni, Trudie Chalder, Harvey Chochinov, Marilène Filbet, Pam Firth, Luigi Grassi, Jane Hutton, Jenny Kieldsen, David Kissane, Nigel Konzon, Iain Lawrie, Sally List, Mari Lloyd Williams, Jon Håvard Loge, Kathryn Mannix, Stirling Moorey, Maria Nabal, Mike Philpot, Holly Prigerson, Lukas Radbruch, Peter Rainey, Vicky Robinson, WadIHJJ Rhondali, Peter Speck, Imke Strohscheer, David Taylor and Maggie Watson for offering their knowledge, experience, opinion and support as members of the expert group.
We thank Stein Kaasa and Dagny Haugen (EPCRC project coordinators) and the EPCRC Core Scientific Group (listed above) for their input and support.
- Endicott J: Measurement of depression in patients with cancer. Cancer. 1984, 53 (10 Suppl): 2243-2249.PubMedGoogle Scholar
- Block SD: Assessing and managing depression in the terminally ill patient. ACP-ASIM End-of-Life Care Consensus Panel. American College of Physicians - American Society of Internal Medicine. Ann Intern Med. 2000, 132 (3): 209-218.View ArticlePubMedGoogle Scholar
- Rayner L, Price A, Evans A, Valsraj K, Hotopf M, Higginson IJ: Antidepressants for the treatment of depression in palliative care: systematic review and meta-analysis. Palliat Med. 2011, 25 (1): 36-51. 10.1177/0269216310380764.View ArticlePubMedGoogle Scholar
- Rayner L, Price A, Evans A, Higginson IJ, Valsraj K, Hotopf M: Antidepressants for depression in physically ill people. Cochrane Database of Systematic Reviews. 2010, Art No.: CD007503-3
- Akechi T, Okuyama T, Onishi J, Morita T, Furukawa TA: Psychotherapy for depression among incurable cancer patients. Cochrane Database Syst Rev. 2008, CD005537-2
- Irwin SA, Rao S, Bower K, Palica J, Rao SS, Maglione JE, Soskins M, Betterton AE, Ferris FD: Psychiatric issues in palliative care: recognition of depression in patients enrolled in hospice care. J Palliat Med. 2008, 11 (2): 158-163. 10.1089/jpm.2007.0140.View ArticlePubMedGoogle Scholar
- Lloyd-Williams M, Friedman T, Rudd N: A survey of antidepressant prescribing in the terminally ill. Palliat Med. 1999, 13 (3): 243-248. 10.1191/026921699676753309.View ArticlePubMedGoogle Scholar
- Rayner L, Price A, Hotopf M, Higginson IJ: The development of evidence-based European guidelines on the management of depression in palliative cancer care. Eur J Cancer. 2011Google Scholar
- Hotopf M, Chidgey J, Addington-Hall J, Ly KL: Depression in advanced disease: a systematic review Part 1. Prevalence and case finding. Palliat Med. 2002, 16 (2): 81-97. 10.1191/02169216302pm507oa.View ArticlePubMedGoogle Scholar
- Gilbody S, Sheldon T, House A: Screening and case-finding instruments for depression: a meta-analysis. CMAJ. 2008, 178 (8): 997-1003. 10.1503/cmaj.070281.View ArticlePubMedPubMed CentralGoogle Scholar
- NICE: Depression in adults with a chronic health problem: treatment and management. 2009, National Institute of Clinical ExcellenceGoogle Scholar
- Lloyd-Williams M, Spiller J, Ward J: Which depression screening tools should be used in palliative care?. Palliat Med. 2003, 17 (1): 40-43. 10.1191/0269216303pm664oa.View ArticlePubMedGoogle Scholar
- Wasteson E, Brenne E, Higginson IJ, Hotopf M, Lloyd-Williams M, Kaasa S, Loge JH: Depression assessment and classification in palliative cancer patients: a systematic literature review. Palliat Med. 2009, 23 (8): 739-753. 10.1177/0269216309106978.View ArticlePubMedGoogle Scholar
- Stiefel R, Die Trill M, Berney A, Olarte JM, Razavi A: Depression in palliative care: a pragmatic report from the Expert Working Group of the European Association for Palliative Care. Support Care Cancer. 2001, 9 (7): 477-488. 10.1007/s005200100244.View ArticlePubMedGoogle Scholar
- Thekkumpurath P, Venkateswaran C, Kumar M, Bennett MI: Screening for Psychological Distress in Palliative Care: A Systematic Review. J Pain Symptom Manage. 2008, 36 (4): 597-605.Google Scholar
- Rayner L, Price A, Evans A, Valsraj K, Hotopf M, Higginson IJ: Antidepressants for the treatment of depression in palliative care: systematic review and meta-analysis. Palliative Medicine published online 8th October 2010. 2010Google Scholar
- Biondo PD, Nekolaichuk CL, Stiles C, Fainsinger R, Hagen NA: Applying the Delphi process to palliative care tool development: lessons learned. Support Care Cancer. 2008, 16 (8): 935-942. 10.1007/s00520-007-0348-2.View ArticlePubMedGoogle Scholar
- Zigmond AS, Snaith RP: The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983, 67 (6): 361-370. 10.1111/j.1600-0447.1983.tb09716.x.View ArticlePubMedGoogle Scholar
- Chochinov HM, Wilson KG, Enns M, Lander S: "Are you depressed?" Screening for depression in the terminally ill. Am J Psychiatry. 1997, 154 (5): 674-676.View ArticlePubMedGoogle Scholar
- Whooley MA, Avins AL, Miranda J, Browner WS: Case-finding instruments for depression. Two questions are as good as many. J Gen Intern Med. 1997, 12 (7): 439-445. 10.1046/j.1525-1497.1997.00076.x.View ArticlePubMedPubMed CentralGoogle Scholar
- Hearn J, Higginson IJ: Development and validation of a core outcome measure for palliative care: the palliative care outcome scale. Palliative Care Core Audit Project Advisory Group. Qual Health Care. 1999, 8 (4): 219-227. 10.1136/qshc.8.4.219.View ArticlePubMedPubMed CentralGoogle Scholar
- Higginson IJ, Donaldson N: Relationship between three palliative care outcome scales. Health Qual Life Outcomes. 2004, 2: 68-10.1186/1477-7525-2-68.View ArticlePubMedPubMed CentralGoogle Scholar
- Siegert RJ, Gao W, Walkey FH, Higginson IJ: Psychological well-being and quality of care: a factor-analytic examination of the palliative care outcome scale. J Pain Symptom Manage. 2010, 40 (1): 67-74. 10.1016/j.jpainsymman.2009.11.326.View ArticlePubMedGoogle Scholar
- Mitchell AJ: Are one or two simple questions sufficient to detect depression in cancer and palliative care? A Bayesian meta-analysis. Br J Cancer. 2008, 98 (12): 1934-1943. 10.1038/sj.bjc.6604396.View ArticlePubMedPubMed CentralGoogle Scholar
- Hawkins J, Lindsay E: We listen but do we hear? The importance of patient stories. Br J Community Nurs. 2006, 11 (9): S6-14.View ArticlePubMedGoogle Scholar
- MacMillan HL, Patterson CJ, Wathen CN, Feightner JW, Bessette P, Elford RW, Feig DS, Langley J, Palda VA, Patterson C, et al: Screening for depression in primary care: recommendation statement from the Canadian Task Force on Preventive Health Care. CMAJ. 2005, 172 (1): 33-35. 10.1503/cmaj.1030823.View ArticlePubMedPubMed CentralGoogle Scholar
- Le Fevre P, Devereux J, Smith S, Lawrie SM, Cornbleet M: Screening for psychiatric illness in the palliative care inpatient setting: a comparison between the Hospital Anxiety and Depression Scale and the General Health Questionnaire-12. Palliat Med. 1999, 13 (5): 399-407. 10.1191/026921699671260095.View ArticlePubMedGoogle Scholar
- Lloyd-Williams M, Dennis M, Taylor F: A prospective study to compare three depression screening tools in patients who are terminally ill. Gen Hosp Psychiatry. 2004, 26 (5): 384-389. 10.1016/j.genhosppsych.2004.04.002.View ArticlePubMedGoogle Scholar
- Schade CP, Jones ER, Wittlin BJ: A ten-year review of the validity and clinical utility of depression screening. Psychiatr Serv. 1998, 49 (1): 55-61.View ArticlePubMedGoogle Scholar
- Cipriani A, Furukawa TA, Salanti G, Geddes JR, Higgins JP, Churchill R, Watanabe N, Nakagawa A, Omori IM, McGuire H, et al: Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis. Lancet. 2009, 373 (9665): 746-758. 10.1016/S0140-6736(09)60046-5.View ArticlePubMedGoogle Scholar
- Saarto T, Wiffen PJ: Antidepressants for neuropathic pain: a Cochrane review. J Neurol Neurosurg Psychiatry. 2010, Published onlineGoogle Scholar
- BNF: British National Formulary. 2010, London: British Medical AssociationGoogle Scholar
- Cankurtaran ES, Ozalp E, Soygur H, Akbiyik DI, Turhan L, Alkis N: Mirtazapine improves sleep and lowers anxiety and depression in cancer patients: superiority over imipramine. Support Care Cancer. 2008, 16 (11): 1291-1298. 10.1007/s00520-008-0425-1.View ArticlePubMedGoogle Scholar
- NICE: Guidance on Cancer Services. Improving Supportive and Palliative Care for Adults with Cancer. 2004, London: National Institute for Clinical ExcellenceGoogle Scholar
- Coventry PA, Gellatly JL: Improving outcomes for COPD patients with mild-to-moderate anxiety and depression: a systematic review of cognitive behavioural therapy. Br J Health Psychol. 2008, 13 (Pt 3): 381-400.View ArticlePubMedGoogle Scholar
- Anderson T, Watson M, Davidson R: The use of cognitive behavioural therapy techniques for anxiety and depression in hospice patients: a feasibility study. Palliat Med. 2008, 22 (7): 814-821. 10.1177/0269216308095157.View ArticlePubMedGoogle Scholar
- Moorey S, Cort E, Kapari M, Monroe B, Hansford P, Mannix K, Henderson M, Fisher L, Hotopf M: A cluster randomized controlled trial of cognitive behaviour therapy for common mental disorders in patients with advanced cancer. Psychol Med. 2009, 39 (5): 713-723. 10.1017/S0033291708004169.View ArticlePubMedGoogle Scholar
- Moadel A, Morgan C, Fatone A, Grenman J, Carter J, Laruffa G, Skummy A, Dutcher J: Seeking meaning and hope: self-reported spiritual and existential needs among an ethnically-diverse cancer patient population. Psycho-oncology. 1999, 8: 378-385. 10.1002/(SICI)1099-1611(199909/10)8:5<378::AID-PON406>3.0.CO;2-A.View ArticlePubMedGoogle Scholar
- Jenkins R, Pargament K: Religion and spirituality as resources for coping with cancer. Journal of Psychosocial oncology. 1995, 13 (1): 51-74. 10.1300/J077V13N01_04.View ArticleGoogle Scholar
- Balboni TA, Paulk ME, Balboni MJ, Phelps AC, Loggers ET, Wright AA, Block SD, Lewis EF, Peteet JR, Prigerson HG: Provision of Spiritual Care to Patients With Advanced Cancer: Associations With Medical Care and Quality of Life Near Death. Journal of Clinical Oncology. 2010, 28 (3): 446-452.View ArticleGoogle Scholar
- Sasahara T, Kizawa Y, Morita T, Iwamitsu Y, Otaki J, Okamura H, Takahashi M, Takenouchi S, Bito S: Development of a standard for hospital-based palliative care consultation teams using a modified Delphi method. J Pain Symptom Manage. 2009, 38 (4): 496-504. 10.1016/j.jpainsymman.2009.01.007.View ArticlePubMedGoogle Scholar
- Price A, Hotopf M, Higginson IJ, Monroe B, Henderson M: Psychological services in hospices in the UK and Republic of Ireland. J R Soc Med. 2006, 99 (12): 637-639. 10.1258/jrsm.99.12.637.View ArticlePubMedPubMed CentralGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1472-684X/10/10/prepub