Table 2 Univariate analysis of prognostic factors of metastatic gastric cancer patients undergoing resection
From: Palliative gastrectomy is beneficial in selected cases of metastatic gastric cancer
Factors | Median survival (months) | 95% CI of median | 1-year (%) | 3-year (%) | P value |
|---|---|---|---|---|---|
Age (years) | 0.003 | ||||
≤ 58 (n = 71) | 10.85 | 9.03–12.67 | 42.3 | 5.1 | |
> 58 (n = 122) | 6.15 | 5.28–7.02 | 23.2 | 3.4 | |
Gender | 0.009 | ||||
Male (n = 126) | 7.23 | 5.42–9.05 | 23.8 | 1.3 | |
Female (n = 67) | 10.98 | 6.19–15.77 | 41.8 | 8.3 | |
Albumin (g/dL) | 0.001 | ||||
≤ 3 (n = 37) | 4.44 | 3.65–5.23 | 17.5 | 0.0 | |
> 3 (n = 129) | 8.52 | 6.54–10.49 | 36.0 | 3.8 | |
ALK-P (U/L) | 0.185 | ||||
≤ 60 (n = 57) | 10.82 | 8.63–13.01 | 42.1 | 4.4 | |
> 60 (n = 92) | 7.10 | 5.33–8.87 | 26.1 | 3.3 | |
Total bilirubin (mg/dL) | 0.359 | ||||
≤ 1.3 (n = 153) | 8.25 | 6.90–9.60 | 32.2 | 4.4 | |
> 1.3 (n = 6) | 3.58 | 0.23–2.94 | 16.7 | 0.0 | |
Gastrectomy | 0.525 | ||||
total (n = 84) | 8.52 | 5.39–11.64 | 33.4 | 3.5 | |
subtotal (n = 89) | 6.61 | 5.05–8.17 | 27.4 | 4.3 | |
Location | 0.161 | ||||
upper (n = 44) | 10.55 | 7.39–13.72 | 41.9 | 7.7 | |
middle (n = 29) | 8.06 | 4.92–11.19 | 36.3 | 0.0 | |
lower (n = 97) | 6.61 | 5.54–7.68 | 24.1 | 5.9 | |
diffuse (n = 22) | 6.38 | 0.60–12.16 | 27.3 | 0.0 | |
Tumor-associated symptoms | 0.008 | ||||
no (n = 83) | 12.63 | 10.04–15.23 | 40.4 | 4.3 | |
yes (n = 110) | 8.88 | 7.21–10.56 | 22.7 | 4.1 | |
Differentiation | 0.549 | ||||
yes (n = 44) | 8.52 | 5.99–11.04 | 34.1 | 2.3 | |
no (n = 149) | 7.10 | 5.35–8.85 | 29.0 | 4.6 | |
Lauren’s classification | 0.445 | ||||
intestinal (n = 57) | 8.91 | 6.44–11.38 | 31.6 | 4.0 | |
diffuse (n = 101) | 6.94 | 4.99–8.88 | 27.2 | 3.8 | |
mixed (n = 31) | 7.23 | 3.55–10.92 | 37.2 | 6.8 | |
T status | 0.143 | ||||
1/2/3 (n = 19) | 10.85 | 8.08–13.62 | 36.8 | 15.8 | |
4 (n = 174) | 7.17 | 5.63–8.701 | 29.4 | 3.4 | |
N status | 0.042 | ||||
0 (n = 12) | 11.67 | 5.14–18.20 | 50.0 | 16.7 | |
1 (n = 12) | 13.71 | 7.24–20.18 | 66.7 | 0.0 | |
2 (n = 32) | 6.54 | 3.78–9.30 | 16.1 | 3.2 | |
3 (n = 137) | 3.94 | 5.24–8.63 | 28.4 | 3.4 | |
LN ratioa | 0.003 | ||||
≤ 0.58 (n = 97) | 10.39 | 8.12–12.66 | 35.4 | 5.9 | |
> 0.58 (n = 96) | 5.56 | 4.24–6.88 | 28.9 | 2.2 | |
No. of lymph node retrieved | 0.881 | ||||
< =15 (n = 47) | 5.03 | 2.47–7.59 | 27.7 | 6.4 | |
> 15 (n = 146) | 8.32 | 6.94–9.70 | 30.9 | 3.1 | |
Resection margins | 0.675 | ||||
Positive (n = 52) | 6.61 | 3.40–9.82 | 32.6 | 0.0 | |
Negative (n = 141) | 8.06 | 6.53–9.58 | 29.3 | 4.8 | |
Vascular invasion | 0.611 | ||||
Positive (n = 70) | 8.52 | 6.42–10.09 | 28.2 | 4.1 | |
Negative (n = 118) | 7.17 | 5.28–9.05 | 27.8 | 3.1 | |
Lymphatic invasion | 0.066 | ||||
Positive (n = 171) | 7.17 | 5.55–8.77 | 28.2 | 4.1 | |
Negative (n = 19) | 11.67 | 7.56–15.79 | 47.4 | 5.3 | |
Perineural invasion | 0.047 | ||||
Positive (n = 147) | 7.17 | 5.53–8.80 | 27.0 | 3.2 | |
Negative (n = 42) | 9.27 | 4.78–13.77 | 41.8 | 7.4 | |
Metastatic pattern | 0.891 | ||||
Hematogenous spread alone (n = 56) | 5.59 | 4.67–6.51 | 28.6 | 6.0 | |
Peritoneum (n = 137) | 8.48 | 7.00–9.96 | 30.8 | 3.2 | |
Chemotherapy | <0.0001 | ||||
No (n = 69) | 4.54 | 2.72–6.36 | 17.7 | 0.0 | |
Yes (n = 124) | 9.73 | 7.77–11.69 | 37.0 | 6.5 |