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Table 6 Factors associated with improvement of fatigue

From: Factors associated with the severity and improvement of fatigue in patients with advanced cancer presenting to an outpatient palliative care clinic

Variable

Full modela

Reduced model

ESAS items

OR

p-value

95% CI

OR

p-value

95% CI

Pain

1.05

0.18

0.98 - 1.12

1.05

0.12

0.99 - 1.12

Nausea

1.03

0.51

0.95 - 1.11

   

Depression

1.02

0.63

0.94 - 1.11

   

Anxiety

0.98

0.63

0.90 - 1.07

   

Appetite

1.08

0.01

1.01 - 1.16

1.09

0.01

1.02 - 1.16

Drowsiness

0.95

0.12

0.88 - 1.02

0.96

0.16

0.90 - 1.02

Feeling of well-being

1.09

0.06

1.00 - 1.19

1.08

0.06

1.00 - 1.17

Shortness of breath

0.97

0.45

0.91 - 1.04

   

Sleep disturbance

1.00

0.93

0.93 - 1.08

   

Anemia

0.86

0.55

0.52 - 1.43

   

Low albumin

1.25

0.50

0.66 - 2.37

   

MDAS items

      

Consciousness

1.41

0.42

0.61 - 3.28

   

Disorientation

0.89

0.65

0.55 - 1.46

   

Memory change

0.78

0.24

0.52 - 1.18

   

Digit Span

0.71

0.27

0.38 - 1.32

0.69

0.16

0.41 - 1.17

Attention

0.55

0.07

0.28 - 1.07

0.57

0.07

0.31 - 1.05

Disorganized thinking

1.26

0.21

0.87 - 1.81

   

Perception distrurbance

0.68

0.23

0.35 - 1.29

   

Delusions

1.20

0.56

0.63 - 2.29

   

Psychomotor activity

1.34

0.58

0.47 - 3.86

   

Sleep disturbance

1.06

0.76

0.73 - 1.54

   

Alcoholism

0.82

0.50

0.46 – 1.46

   

Cancer Types b

      

Breast

0.84

0.66

0.38 – 1.85

   

Gastrointestinal

1.07

0.80

0.63 - 1.81

   

Genitourinary

1.92

0.04

1.02 - 3.62

1.74

0.04

1.01 - 2.99

Gynecologic

1.19

0.65

0.56 - 2.53

   

Sarcoma

1.34

0.47

0.60 - 3.01

   

Others c

1.17

0.60

0.65 - 2.11

   
  1. ESAS: Edmonton symptom assessment scale; MDAS: Memorial delirium assessment scale;
  2. a- Logistic regression model.
  3. b- Reference: Head & Neck or Lung cancer.
  4. c- Unknown primary, melanoma, skin, leukemia, lymphoma, brain.