Medication | Pop | CG | RA | Num* | TSL (days) | Dose | DT (days) | Key Outcome Measures | Article |
---|---|---|---|---|---|---|---|---|---|
Nortriptyline | Senior | Y | Y-NE | 80/66 | 216–279 | Steady-state plasma level: 50–120 ng/mL | 112 | Depression (HAM-D); Grief (TRIG) | Reynolds, Miller, et al, 1999** |
 | Senior | Y | Y-NE | 27/27 | 210 (mean) | Steady-state plasma level: 79.9+/-28.3 ng/mL Daily dose: 70.8+/-22.2 mg | <180 | Sleep (PSQI); Depression (HAM-D, BDI) | Taylor, Reynolds, et al, 1999 |
 | Senior | Y | NR | 30/24 | 276 | Steady-state plasma level: 72.7 ng/mL Daily dose: 53.0 mg | 112 | Sleep (PSQI) | Pasternak, Reynolds, et al, 1994 |
 | Senior | N | NA | 13/13 | 150–750 | Daily dose: 49.2 mg | 9–184 | Depression (HAM-D, BDI, BSI); Grief (TRIG, JGI); Sleep (PSQI) | Pasternak, Reynolds, et al, 1991 |
Nortriptyline and Paroxetine | Adult | N | NA | 21/15 | 183–4158 | PT Daily dose: 20–50 mg NT Daily dose: 50–160 mg | 120 | Depression (HAM-D); Grief (ICG); Sleep (PSQI) | Zygmont, Prigerson, et al, 1998 |
Desipramine | Adult | N | NA | 10/9 | NR | Daily dose: 75–150 mg | 28 | Depression (HDRS, CGI, Raskin DS); Grief (Separation Distress) | Jacobs, Nelson, et al, 1987 |
Bupropion | Adult | N | NA | 22/14 | 42–56 | Daily dose: 150–300 mg | 56 | Grief (TRIG, ICG); Depression (HAM-D) | Zisook, Schuchter, et al, 2001 |
Diazepam | Senior | Y | Y | 35/30 | <14 | 2 mg/pill, self-administered | <42 | Bereavement (BPQ) | Warner, Metcalfe, et al, 2001 |