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Table 3 Morphine equivalent daily dose by time in subjects with intermittent exposure

From: Dose patterns in commercially insured subjects chronically exposed to opioids: a large cohort study in the United States

Years Number of subjects Mean ± SD Median Min Max P25 P75 P95
Half year 48367 62.48 ± 76.43 50.00 0.25 2700.00 37.50 69.17 112.50
> 6 months to 1 year 22494 57.61 ± 85.68 45.00 0.33 6666.67 31.50 65.16 112.50
> 1 to 1.5 years 19130 56.07 ± 69.1 45.00 0.50 2250.00 30.00 64.11 112.50
> 1.5 to 2 years 15553 56.97 ± 73.8 45.00 0.50 2025.00 30.00 65.00 112.50
> 2 to 2.5 years 11588 58.45 ± 69.05 46.15 0.67 1920.00 30.00 67.50 113.44
> 2.5 to 3 years 8119 60.73 ± 82.99 46.88 0.67 1920.00 30.94 67.50 120.00
> 3 to 3. 5 years 5824 58.23 ± 81.27 45.00 1.56 2660.63 30.00 64.29 112.50
> 3. 5 to 4 years 4677 55.71 ± 75.7 45.00 2.50 1808.04 30.00 60.00 112.50
> 4 to 4.5 years 4619 58.57 ± 87.44 45.00 2.50 2025.00 30.00 60.00 120.00
> 4.5 to 5 years 4111 59.42 ± 100.09 45.00 2.50 2700.00 30.00 60.00 112.50
> 5 to 5.5 years 3418 58.56 ± 96.34 45.00 2.50 3535.12 30.00 60.00 120.00
> 5.5 to 6 years 3301 62.96 ± 113.2 45.00 2.50 2890.19 30.00 61.25 120.00
> 6 to 6.5 years 3225 61.66 ± 109.87 45.00 2.45 3368.28 30.00 62.00 120.00
> 6.5 to 7 years 3031 61.81 ± 101.48 45.00 2.50 2239.86 30.00 60.99 114.28
> 7 to 7.5 years 1837 64.44 ± 116.78 45.00 3.75 2695.92 30.00 60.00 128.57
> 7.5 to 8 years 714 62.71 ± 103.76 45.00 4.17 1350.00 30.00 56.25 146.93
> 8 years 179 72.52 ± 124.42 46.32 6.94 937.50 28.75 60.00 300.00
  1. SD, standard deviation; P25, 25th percentile; P75; 75th percentile; P95; 95th percentile