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Table 6 Morphine equivalent median daily doses in subjects continuously exposed to opioids by time and by permanence in the cohort

From: Dose patterns in commercially insured subjects chronically exposed to opioids: a large cohort study in the United States

Time period Number of subjects who did not continue Median dose in subjects who did not continue Number of subjects who continued exposure Median dose in subjects who continued exposure
Half year 166 56.25 453 45.0
> 6 months to 1 year 200 48.21 253 44.4
> 1 to 1.5 years 107 51.45 145 45.0
> 1.5 to 2 years 60 46.07 86 49.75
> 2 to 2.5 years 48 45.67 38 60.0
> 2.5 to 3 years 14 75.5 24 54.06
> 3 to 3. 5 years 5 60 19 52.2
> 3. 5 to 4 years 2 47.14 17 45.0
> 4 to 4.5 years 4 30.52 13 60.0
> 4.5 to 5 years 4 37.5 9 96.0
> 5 to 5.5 years 0 -- 9 156.4
> 5.5 to 6 years 1 240.0 8 120.0
> 6 to 6.5 years 1 240.0 7 75.0
> 6.5 to 7 years 4 49.8 3 210.0
> 7 to 7.5 years 1 381.7 2 123.4
> 7.5 to 8 years 1 210.0 1 45.0
Median dose   56.25   45.0