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Table 3 Published studies evaluating prospectively the incidence of Pain Flare

From: Incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: multicenter prospective observational study

Author Number of evaluable patients RT technique RT dose schedules (Gy/fx) Pain Flare Incidence (%)
Chow 88 3DCRT 8 Gy / 1fx 2 – 16 %
20 Gy 5 fx
30 Gy /10 fx
Loblaw 44 3DCRT 8Gy / fx 40.9 %
20 Gy/ 5 fx
Hird 111 3DCRT 8 Gy / 1 fx 40 %
20 Gy 5 fx
30 Gy /10 fx
Chiang 41 SBRT 20-24 Gy / 1 fx 68.3 %
24–35 Gy / 2–5 fx
Gomez-Iturriaga 135 3DCRT 8Gy / fx 37.7 %
20 Gy/ 5 fx
  1. Abbreviations: 3DCRT: Tridimensional Conformal Radiotherapy: SBRT: Stereotactic Body Radiotherapy