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Table 3 Published studies evaluating prospectively the incidence of Pain Flare

From: Incidence of pain flare following palliative radiotherapy for symptomatic bone metastases: multicenter prospective observational study

Author

Number of evaluable patients

RT technique

RT dose schedules (Gy/fx)

Pain Flare Incidence (%)

Chow

88

3DCRT

8 Gy / 1fx

2 – 16 %

20 Gy 5 fx

30 Gy /10 fx

Loblaw

44

3DCRT

8Gy / fx

40.9 %

20 Gy/ 5 fx

Hird

111

3DCRT

8 Gy / 1 fx

40 %

20 Gy 5 fx

30 Gy /10 fx

Chiang

41

SBRT

20-24 Gy / 1 fx

68.3 %

24–35 Gy / 2–5 fx

Gomez-Iturriaga

135

3DCRT

8Gy / fx

37.7 %

20 Gy/ 5 fx

  1. Abbreviations: 3DCRT: Tridimensional Conformal Radiotherapy: SBRT: Stereotactic Body Radiotherapy