| 1st line chemotherapy | 2nd line chemotherapy | ||
---|---|---|---|---|
Cancer site | Regimen (reference) | Expected PFS [months] | Regimen (reference) | Expected PFS [months] |
Colon/rectum | 9 | 5 | ||
Pancreas | 4 | fluoropyridimine +/− oxaliplatin [41] | 2 | |
Stomach/esophagus | fluoropyrimidine/platinum +/− trastuzumab for HER2 positive [42–44] | 6 | taxane or irinotecan [45] | 3 |
Anal | 5FU/platinum [46] | 6 | - | - |
Cholangiocarcinoma | Gemcitabine +/− Cisplatin [47] | 6 | - | - |