Skip to main content

Table 3 Pharmacological Management of Anxiety

From: ‘Worried to death’: the assessment and management of anxiety in patients with advanced life-limiting disease, a national survey of palliative medicine physicians

Most frequently prescribed medication

Prognosis days-weeks

Prognosis months

n (%)

n (%)

1st Line

 

( n= 216)

( n= 211 )

Benzodiazepine (BZ)

200 (93)

99 (47)

Alone

188 (87)

78 (37)

Combined (with another drug class)

12 (6)

21 (10)

Where BZ specified:

 (n = 147)

 (n = 73)

 Lorazepam

 127 (86)

 60 (8)

 Diazepam

 11 (7)

 13 (18)

 Midazolam

 8 (5)

 0 (0)

Antidepressant (AD)

21 (10)

127 (60)

Alone

12 (6)

107 (51)

Combined (with BZ)

9 (4)

20 (9)

Where AD specified:

 (n = 17)

 (n = 93)

 Mirtazapine

 12 (71)

 35 (38)

 Citalopram

 3 (18)

 50 (54)

 Sertraline

 2 (12)

 6 (6)

Other Medications

 Haloperidol

4 (2)

2 (1)

 Levomepromazine

2 (1)

0 (0)

 Pregabalin

0 (0)

4 (2)

2nd Line

 

( n= 142)

( n= 124)

Benzodiazepine

99 (70)

57 (46)

Where BZ specified:

 (n = 96)

 (n = 49)

 Midazolam

 46 (48)

 4 (8)

 Diazepam

 31 (32)

 16 (33)

 Lorazepam

 18 (19)

 29 (59)

Antidepressant

26 (18)

55 (44)

Where AD specified:

 (n = 18)

 (n = 41)

 Mirtazapine

 9 (50)

 22 (54)

 Amitriptyline

 4 (22)

 1 (2)

 Citalopram

 3 (17)

 11 (27)

 Sertraline

 1 (6)

 5 (12)

Other Medications

 Levomepromazine

9 (6)

3 (2)

 Pregabalin

2 (1)

8 (6)

 Morphine

2 (1)

3 (2)

 Unspecified antipsychotic

3 (2)

0 (0)

  1. Medications used by n = 1 or less respondents in both prognostic groups not included in table
  2. n numbers: variation as non-compulsory free text answers so some respondents answered only part of question, some specified drug and others only gave drug class