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Table 3 Comparison between patients who died during 2006–2010 and those who died during 2011–2015

From: Trends in treatment during the last stages of life in end-stage gynecologic cancer patients who received active palliative chemotherapy: a comparative analysis of 10-year data in a single institution

Parameter

2006–2010 (N = 92)

2011–2015 (N = 101)

p-value

Age (years), SD

53.2 ± 13.07

55.4 ± 9.48

0.192

Marital status

  

0.136

 Married

74 (80.4)

89 (88.1)

 

 Non-married (single)

11 (14.0)

4 (4.0)

 

 Widowed or divorced

7 (7.6)

8 (7.9)

 

Parity

  

0.180

 0

17 (18.5)

10 (9.9)

 

 1

13 (14.1)

20 (19.8)

 

  ≥ 2

62 (67.4)

71 (70.3)

 

Primary cancer

  

0.350

 Ovarian cancer

57 (62.0)

53 (52.5)

 

 Cervical cancer

16 (17.4)

23 (22.8)

 

 Uterine cancer

15 (16.3)

23 (22.8)

 

 Vagina or vulvar cancer

4 (4.3)

2 (2.0)

 

FIGO stage

  

0.447

 I

10 (10.9)

16 (15.8)

 

 II

16 (17.4)

2 (14.5)

 

 III

47 (51.1)

47 (46.5)

 

 IV

19 (20.7)

26 (25.7)

 

ECOG PS score at the last admission

  

0.248

 0

41 (44.6)

31 (30.7)

 

 1

24 (26.1)

30 (29.7)

 

 2

12 (13.0)

23 (22.8)

 

 3

10 (10.9)

10 (9.9)

 

 4

5 (5.4)

7 (6.9)

 

Reason for last admission

  

0.775

 Procedure or palliative treatment

16 (17.4)

12 (11.9)

 

 Gastrointestinal symptoms

25 (27.2)

27 (26.7)

 

 Cardiovascular or pulmonary symptoms

17 (18.5)

22 (21.8)

 

 Infectious state

11 (12.0)

20 (19.8)

 

 Uncontrolled pain

6 (6.5)

5 (5.0)

 

 Hematologic instability

7 (7.6)

5 (5.0)

 

 Neurologic symptoms

3 (3.3)

4 (4.0)

 

 Others

7 (7.6)

6 (5.9)

 

ICU admission in the last month

11 (12.0)

12 (11.9)

0.987

Imaging examination conducted in the last month

  

0.011

 No examination

35 (38.0)

21 (20.8)

 

 Examination (CT, MRI, PET-CT)

57 (62.0)

80 (79.2)

 

Type of treatment administered during the last 6 mo

  

0.004

 Chemotherapy alone

82 (89.1)

73 (72.3)

 

 Chemotherapy with radiation or surgery

10 (10.9)

28 (27.7)

 

Type of chemotherapy-agent administered during the last 6 mo

  

0.199

 IV only

87 (94.6)

90 (89.1)

 

 IV with PO

5 (5.4)

11 (10.9)

 

Number of total palliative chemotherapy sessions

3.08

3.24

0.587

Frequency of admission during the last 6 mo

5.12

6.06

0.003

Frequency of chemotherapy during the last 6 mo

3.84

4.93

<  0.001

Invasive procedure during the last 3 mo

38 (41.3)

57 (56.4)

0.044

Duration from last admission to death (d)

27.0

24.3

0.535

Duration from last chemotherapy to death (d)

58.1

47.0

0.067

Date of last chemotherapy before death

  

0.486

 Between the last 3 mo and 6 mo

20 (21.7)

18 (17.8)

 

 Between the last 1 mo and 3 mo

47 (51.1)

45 (44.6)

 

 Between the last 1 mo and 2 wk

12 (13.0)

19 (18.8)

 

 Within the last 2wk

12 (13.0)

20 (19.8)

 
  1. Data are presented as mean (range) or n (%) unless otherwise specified
  2. Invasive procedure: paracentesis, thoracentesis, insertion or removal of catheters or stents in vessels or organs excluding the surgery