The Prognosis in Palliative care Study II (PiPS2): study protocol for a multi-centre, prospective, observational, cohort study

Table 1 Data required for the calculation of prognostic models

Variable	Prognostic model
Variable	PiPS-A	PiPS-B	PPI	PPS^a	PaP	FPN
ECOG performance status	X	X				X
General health status	X	X
Abbreviated Mental Test Score > 3	X	X
Primary breast cancer	X
Primary prostate cancer	X	X
Distant metastases (any)	X	X
Liver metastases	X
Bone metastases	X	X
Anorexia	X	X			X
Dysphagia	X
Dyspnoea	X		X		X
Weight loss in last month	X
Pulse rate	X	X
Fatigue		X
PPS^a score			X	X
Oral intake			X
Oedema			X
Delirium			X
CES					X
KPS					X
Time to terminal disease^b						X
Blood Results:
White blood count		X			X
Lymphocyte count		X			X	X
Neutrophil count		X
Platelet count		X
Urea		X
Albumin		X				X
Alkaline phosphatase		X
Alanine transaminase		X
C-Reactive protein		X
Lactate dehydrogenase						X

^aDespite PPS being designed as a measure of functional status, it does have prognostic significance and was therefore included in the prognostic models this study intends to validate. PPS is listed in both “Variable” and “Prognostic Model” sections as it is one of the variables used for the calculation of the PPI score ^bTime to terminal disease refers to the time between the initial cancer diagnosis and the date at which the cancer became incurable (i.e., time at which deemed to be inoperable or became metastatic)

ISSN: 1472-684X