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Table 2 Overview of blood samples obtained at all visits

From: The Palliative Radiotherapy and Inflammation Study (PRAIS) - protocol for a longitudinal observational multicenter study on patients with cancer induced bone pain

Clinical chemistry

Hemoglobin, white blood cells, differential white cell count, platelets, creatinine, urea, bilirubin, potassium, sodium, chloride, total calcium, phosphate, magnesium, CRP, albumin, triglycerides, vitamin-D

Inflammatory biomarkers

High-sensitivity CRP, IL-1β, IL-1, IL-1ra, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8/CXCL-8, IL-9, IL-10, IL-12 (p70), IL-13, IL-15, IL-17, basic fibroblast growth factor (bFGF), granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-ɣ), eotaxin/CCL11, IFN-ɣ-inducible protein (IP-10)/CXCL10, MCP-1)/CCL2, MIP-1α/CCL3), MIP-1β/CCL4, regulated on activation, normal T-cell expressed and secreted (RANTES)/CCL5, TNF, platelet-derived growth factor (PDGF), and vascular endothelial growth factor (VEGF).

Biomarkers involved in bone remodelling

RANK-ligand (RANKL), Osteoprotegerin (OPG) and Notch Ligands: DLL1 and Periostin.