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Table 2 Laxative use at opioid prescription

From: Optimal treatment of opioid induced constipation in daily clinical practice – an observational study

  Total
N = 327 (%)
Fentanyl maintenance
N = 131 (%)
Oxycodone maintenance
N = 90 (%)
P (fentanyl vs. oxycodone group)
Any laxative 195 (60) 88 (67) 63 (70) 0,657
Polyethylene glycol solution 181 (55) 78 (60) 60 (67) 0,283
 PEG dose, mediana 1 1 1  
Magnesium 23 (7) 13 (10) 5 (6) 0,243
 Magnesium dose, medianb 3 3 6  
Bisacodyl 3 (1) 3 (2) 0 (0) 0,148
 Bisacodyl dose, medianc 1 1 .  
Lactulose 7 (2) 3 (2) 2 (2) 0,973
 Lactulose dose, mediand 1 1 2  
Enema’s 18 (6) 5 (4) 7 (8) 0,202
 Enema frequency, mediane 1 1 1  
Other 3 (1) 2 0 (0) 0,239
  1. aNumber of polyethylene glycol sachets per day. Sachet à 13,7 g containing polyethylene glycol and elektrolytes (potassiumchloride, sodiumchloride, sodium hydrogen carbonate). Inter quartile range (IQR) total group: 1–2; fentanyl group: 1–2; oxycodone group: 1–2
  2. bNumber of magnesium oxide tablets à 500 mg per day. IQR total group: 2–6; fentanyl group 2–3; oxycodone group: 4–6
  3. cNumber of bisacodyl tablets à 5 mg per day. Range total group: 1–1; fentanyl group: 1–1; oxycodone group: not applicable
  4. dNumber of lactulose doses per day. One dose equals 15 ml of lactulose 670 mg/ml. Range total group: 0–2; fentanyl group: 0–2; oxycodone group: 0–2
  5. eNumber of enema’s per day, usually a sodium phosphate enema of 133 ml containing 31,8 mg sodium acid phosphate and 139,1 mg sodium dihydrogenphosphate per ml. IQR total group: 0,5–1; fentanyl group: 0–1; oxycodonde group: 0,5–1