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Table 1 Examples of treatment related adverse events

From: Opioid therapy vs. multimodal analgesia in head and neck Cancer (OPTIMAL-HN): study protocol for a randomized clinical trial

Structure Adverse Event
Cardiac Asystole
Cardiac Arrest
Myocardial Infarction
Gastrointestinal Constipation
Dry mouth
Oral Mucositis
Nausea
Vomiting
Lower gastrointestinal hemorrhage
Upper gastrointestinal hemorrhage
Duodenal hemorrhage
Duodenal ulcer
Duodenal perforation
Dyspepsia
Gastric hemorrhage
Gastric ulcer
Gastric perforation
Colonic perforation
Small bowel perforation
General disorders Death NOS
Localized edema e.g. peripheral or facial
Fatigue
Investigations Alanine aminotransferase increased
Aspartate aminotransferase increased
Alkaline phosphatase increased
INR increased
Prothrombin time prolonged
Total, direct, or indirect bilirubin increased
Hypoalbuminemia
Creatinine increased
Hyperkalemia
Weight gain
Nervous system disorders Cognitive disturbance
Concentration impairment
Depressed level of consciousness
Lethargy
Memory impairment
Somnolence
Stroke
Transient ischemic attacks
Dizziness
Blurred vision
Vision decreased
Headache
Ataxia
Psychiatric disorders Confusion
Delirium
Hallucinations
Insomnia
Suicidal ideation
Renal and urinary disorders Acute kidney injury
Skin disorder Pruritis
Dermatitis (either radiation-related or exfoliative)
Stevens-Johnson Syndrome
Toxic Epidermal Necrolysis
Immune system disorders Anaphylaxis
Hematologic disorders Anemia
Agranulocytosis
Thrombocytopenia
Aplastic anemia
Febrile neutropenia
Musculoskeletal and connective tissue disorders Rhabdomyolysis