From: Use of antithrombotics at the end of life: an in-depth chart review study
Heparins |
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1. 87-year-old woman with an intracerebral tumor and secondary epilepsy for which she receives comfort care. Further hypothyroidism and dyslipidemia. Acetylsalicylic acid 1dd 80Â mg Comedication: dexamethasone 2dd 2Â mg, phenytoin 2dd 150Â mg, gemfibrozil 1dd 600Â mg, levetiracetam 2dd 1000Â mg, pantoprazole 1dd 40Â mg, paracetamol 3dd 1000Â mg p.r.n., temazepam 1dd 10Â mg a.n., thyroxine 1dd 0.025Â mg She is admitted at the hospital because of persisting partial convulsions. In between she is lucid and well-oriented. Clonazepam 2dd 0.5Â mg is added and levetiracetam is gradually increased up to 2dd 1750Â mg. Valproic acid 2dd 500Â mg is added, and clonazepam increased up to 3dd 2Â mg. Midazolam s.c. is titrated as needed 0.5-5Â mg. Nadroparin 1dd 2850 IE is started six days after admission because of bedriddenness. She develops an expressive aphasia and agitation. Haloperidol 1Â mg as needed is added. Two and a half weeks after admission she turns unconscious. All medication is continued until death. |
2. 53-year-old man at home with pancreatic carcinoma and IDDM. Medication: amlodipine/valsartan 1dd 10/160Â mg, diclofenac 2dd 75Â mg, fentanyl transdermal 25 mcgr/h, haloperidol 2dd 1Â mg, insulin pump s.c., omeprazole 1dd 40Â mg, paracetamol 4dd 1000Â mg, natriumlaurylsulfoacetate/natriumcitrate/sorbitol rectal p.r.n. Because of increasing pain diclofenac is increased to 3dd 75Â mg and fentanyl nasal 50 mcg/dose as needed is added. After two weeks the fentanyl nasal is increased to 100 mcg/dose as needed. One week later tinzaparin 1dd 18,000 IE is started because of clinical signs of a deep venous thrombosis on the calf. Diclofenac and fentanyl is stopped and a morphine pump is started s.c. 5Â mg/h and bolus 4Â mg s.c. as needed. Amlodipine/valsartan is stopped because of low blood pressure. A week later palliative sedation is started with midazolam pump s.c. up to 15Â mg/h. The oral medication is stopped, tinzaparin is continued. He passes away two days later. |
3. 77-year-old woman with metastasized esophageal carcinoma and deep venous thrombosis is admitted to a hospice. Previous history: arterial hypertension, genital cancer, urinary tract infection. Nadroparin (Fraxiparine forte) 1dd 15,200 IE Comedication at admission: fentanyl transdermal 12 mcgr/h every 3 days, hydrochlorothiazide 1dd 12,5Â mg, macrogol/electrolytes 1dd 1 sachet every two days, oxazepam 3dd 20Â mg p.r.n., oxycodone IR 6dd 5Â mg p.r.n., paracetamol 4dd 1000Â mg p.r.n., temazepam 1dd 20Â mg a.n. Two days after admission the hydrochlorothiazide is stopped, and haloperidol 1dd 1Â mg and nitrofurantoin 4dd 50Â mg is started because of signs of a delirium and cystitis. Fentanyl is switched to morphine retard 2dd 20Â mg orally and morphine 5Â mg 6dd orally as needed, because of pain and dyspnea. After two weeks morphine retard is increased to 2dd 30Â mg because of dyspnea. After one week morphine 15Â mg/24Â h, haloperidol 2,5Â mg/24Â h and midazolam 42Â mg/24Â h is started s.c. because of refractory dyspnea and delirium. Oral medication is discontinued. She dies one day later. Nadroparin was continued until death. |