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Table 1 Characteristics of 7,879 patients with metastatic non-small cell lung cancer by receipt of chemotherapy

From: The effect on survival of continuing chemotherapy to near death

Variables No chemotherapy
(n = 4,345)
Standard chemotherapy
(n = 3,235)
Aggressive -approach chemotherapy
(n = 299)
P-value
      3 groups No chemo-therapy vs. Chemo- therapy* Standard chemotherapy vs. Aggressive -approach chemotherapy
Age at diagnosis, years Median [IQR] 73.0 [69.0-78.0] 71.0 [68.0-74.0] 70.0 [67.0-74.0] < 0.001 < 0.001 0.36
Gender, n (%) Female 1,938 (44.6) 1,291 (39.9) 108 (36.1) < 0.001 < 0.001 0.20
  Male 2,407 (55.4) 1,944 (60.1) 191 (63.9)    
Charlson comorbidity index, n (%) 0 3,123 (71.9) 2,401 (74.2) 226 (75.6) < 0.001 < 0.001 0.06
  1 773 (17.8) 576 (17.8) 60 (20.1)    
  2 ≤ 449 (10.3) 258 (8.0) 13 (4.4)    
Race/Ethnicity, n (%) non-Hispanic white 3,551 (81.7) 2,711 (83.8) 254 (85.0) 0.01 0.01 0.22
  non-Hispanic black 425 (9.8) 248 (7.7) 21 (7.0)    
  Hispanic or other 369 (8.5) 276 (8.5) 24 (8.0)    
Region of tumor registries, n (%) Northeast 672 (15.5) 555 (17.2) 51 (17.1) < 0.01 < 0.01 0.06
  South 228 (5.3) 194 (6.0) 28 (9.4)    
  Midwest 1,426 (32.8) 1,101 (34.0) 86 (28.8)    
  West 2019 (46.5) 1385 (42.8) 134 (44.8)    
Urban residence, n (%) Yes 3,928 (90.4) 2,973 (91.9) 284 (95.0) < 0.01 < 0.01 0.06
  No 417 (9.6) 262 (8.1) 15 (5.0)    
Socioeconomic status, n (%) Highest quintile 763 (17.6) 682 (21.1) 71 (23.8) < 0.001 < 0.001 0.85
  Fourth quintile 793 (18.3) 673 (20.8) 63 (21.1)    
  Third quintile 866 (19.9) 688 (21.3) 59 (19.7)    
  Second quintile 849 (19.5) 635 (19.6) 56 (18.7)    
  Lowest quintile 1,074 (24.7) 557 (17.2) 50 (16.7)    
Median income Median
[IQR]
38,154 [29-152] 41,205 [32-757] 43,564 [32-179] < 0.001 < 0.001 0.28
Teaching hospital, n (%) Yes 2,110 (48.6) 1,868 (57.7) 163 (54.5) < 0.001 < 0.001 0.28
  No 2,235 (51.4) 1,367 (42.3) 136 (45.5)    
Year of death, n (%) 1991 365 (8.4) 206 (6.4) 18 (6.0) < 0.001 < 0.001 0.02
  1992 576 (13.3) 299 (9.2) 22 (7.4)    
  1993 567 (13.1) 340 (10.5) 15 (5.0)    
  1994 581 (13.4) 339 (10.5) 33 (11.0)    
  1995 518 (11.9) 372 (11.5) 33 (11.0)    
  1996 490 (11.3) 424 (13.1) 32 (10.7)    
  1997 442 (10.2) 413 (12.8) 46 (15.4)    
  1998 421 (9.7) 421 (13.0) 52 (17.4)    
  1999 385 (8.9) 421 (13.0) 48 (16.1)    
Death in the hospital, n (%) Yes 774 (17.8) 812 (25.1) 152 (50.8) < 0.001 < 0.001 < 0.001
  No 3,571 (82.2) 2,423 (74.9) 147 (49.2)    
ICU admission within 1 month of death, n (%) Yes 187 (4.3) 213 (6.6) 37 (12.4) < 0.001 < 0.001 < 0.001
  No 4,158 (95.7) 3,022 (93.4) 262 (87.6)    
More than 1 ER visit within 1 month of death, n (%) Yes 870 (20.0) 857 (26.5) 104 (34.8) < 0.001 < 0.001 < 0.01
  No 3,475 (80.0) 2,378 (73.5) 195 (65.2)    
Hospice admission, n (%) None 2,208 (50.8) 1,668 (51.6) 241 (80.6) < 0.001 < 0.001 < 0.001
  Three or fewer days 156 (3.6) 198 (6.1) 25 (8.4)    
  Four or more days 1,981 (45.6) 1,369 (42.3) 33 (11.0)    
  1. Abbreviation: vs., versus; IQR, interquartile range; ICU, intensive care unit; ER, emergency room.
  2. *Chemotherapy includes standard chemotherapy or aggressive-approach chemotherapy