Table 3 Description of indications

1

Non-specific: to include lack of appetite, wellbeing, fatigue nausea, vomiting, pain and shortness of breath

2

Neurological to include: raised intracranial pressure, cerebral tumours, spinal cord compression and nerve compression or infiltration

3

Capsular stretching: to include liver metastases and other visceral organ metastases

4

Soft tissue infiltration: to include head and neck tumours and abdominal and pelvic tumours

5

Tenesmus: rectal pain due to invasive tumours

6

Inflammation with syringe driver sites (subcutaneous route)

7

Not clear/other: to include any indication, which was either not clear or did not fit in the other categories

8

Chemotherapy