Dose patterns in commercially insured subjects chronically exposed to opioids: a large cohort study in the United States

Table 4 Morphine equivalent daily dose by time in subjects with continuous exposure without cancer diagnosis

Years	Number of subjects	Mean ± SD	Median	Min	Max	P25	P75	P95
Half year	442	62.53 ± 69.88	45.04	7.5	802.13	30.54	67.5	142.5
> 6 months to 1 year	305	62.11 ± 65.73	45	7.5	486.86	30	64.29	170
> 1 to 1.5 years	173	66.37 ± 64.39	46.61	7.5	480	30	73.5	197.14
> 1.5 to 2 years	107	64.6 ± 62.1	45.8	7.5	342.86	30	64.29	184.85
> 2 to 2.5 years	67	71.96 ± 70.86	50.63	8.33	360	30	82.12	183.33
> 2.5 to 3 years	29	88.2 ± 91.12	60	8.33	420	39.99	95.45	330
> 3 to 3. 5 years	19	91.05 ± 115.16	53.09	8.33	480	30	90.91	480
> 3. 5 to 4 years	14	68.13 ± 53.39	52.5	15	187.5	24.64	107.76	187.5
> 4 to 4.5 years	12	90.38 ± 79.83	52.5	15	244.55	30	169	244.55
> 4.5 to 5 years	9	80.99 ± 61.23	60	22.5	183	45	95.98	183
> 5 to 5.5 years	6	111.56 ± 72.04	117.18	22.5	187.5	45	180	187.5
> 5.5 to 6 years	6	122.59 ± 89.37	120.27	22.5	240	45	187.5	240
> 6 to 6.5 years	5	122.88 ± 105.75	75	22.5	255	45	216.92	255
> 6.5 to 7 years	5	133.5 ± 132.31	60	22.5	330	45	210	330
> 7 to 7.5 years	2	123.41 ± 110.89	123.41	45	201.82	45	201.82	201.82
> 7.5 to 8 years	2	127.5 ± 116.67	127.5	45	210	45	210	210
> 8 years	1	45 ± .	45	45	45	45	45	45

SD, standard deviation; P25, 25^th percentile; P75; 75^th percentile; P95; 95^th percentile

ISSN: 1472-684X