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Table 4 Morphine equivalent daily dose by time in subjects with continuous exposure without cancer diagnosis

From: Dose patterns in commercially insured subjects chronically exposed to opioids: a large cohort study in the United States

Years Number of subjects Mean ± SD Median Min Max P25 P75 P95
Half year 442 62.53 ± 69.88 45.04 7.5 802.13 30.54 67.5 142.5
> 6 months to 1 year 305 62.11 ± 65.73 45 7.5 486.86 30 64.29 170
> 1 to 1.5 years 173 66.37 ± 64.39 46.61 7.5 480 30 73.5 197.14
> 1.5 to 2 years 107 64.6 ± 62.1 45.8 7.5 342.86 30 64.29 184.85
> 2 to 2.5 years 67 71.96 ± 70.86 50.63 8.33 360 30 82.12 183.33
> 2.5 to 3 years 29 88.2 ± 91.12 60 8.33 420 39.99 95.45 330
> 3 to 3. 5 years 19 91.05 ± 115.16 53.09 8.33 480 30 90.91 480
> 3. 5 to 4 years 14 68.13 ± 53.39 52.5 15 187.5 24.64 107.76 187.5
> 4 to 4.5 years 12 90.38 ± 79.83 52.5 15 244.55 30 169 244.55
> 4.5 to 5 years 9 80.99 ± 61.23 60 22.5 183 45 95.98 183
> 5 to 5.5 years 6 111.56 ± 72.04 117.18 22.5 187.5 45 180 187.5
> 5.5 to 6 years 6 122.59 ± 89.37 120.27 22.5 240 45 187.5 240
> 6 to 6.5 years 5 122.88 ± 105.75 75 22.5 255 45 216.92 255
> 6.5 to 7 years 5 133.5 ± 132.31 60 22.5 330 45 210 330
> 7 to 7.5 years 2 123.41 ± 110.89 123.41 45 201.82 45 201.82 201.82
> 7.5 to 8 years 2 127.5 ± 116.67 127.5 45 210 45 210 210
> 8 years 1 45 ± . 45 45 45 45 45 45
  1. SD, standard deviation; P25, 25th percentile; P75; 75th percentile; P95; 95th percentile