Table 2 Serum and urine concentrations of morphine, metabolites, and metabolic ratios (n = 24)
Median | Mean | Range | |
|---|---|---|---|
Serum | |||
Day1 | |||
M (nmol/l) | 268.8 | 5617.8 | 35.0–70302.6 |
M6G (nmol/l) | 216.7 | 613.6 | 21.7–5229.1 |
M3G (nmol/l) | 1036.6 | 2372.8 | 108.4–24160.2 |
M6G/M (nmol/l) | 0.6 | 1.6 | 0.0–9.3 |
M3G/M (nmol/l) | 3.1 | 5.0 | 0.1–21.5 |
Urine | |||
Day1 | |||
M (nmol/l) | 33293.9 | 253924.0 | 1051.4–1380117.6 |
M6G (nmol/l) | 11485.3 | 31195.6 | 1267.3–268278.9 |
M3G (nmol/l) | 34780.8 | 81053.0 | 3828.9–518352.5 |
M6G/M (nmol/l) | 0.8 | 0.8 | 0.0–2.0 |
M3G/M (nmol/l) | 1.7 | 1.9 | 0.1–5.6 |
Day2 | |||
M (nmol/l) | 23130.5 | 407484.6 | 1401.8–3078804.8 |
M6G (nmol/l) | 10726.8 | 72322.2 | 1733.6–1177133.4 |
M3G (nmol/l) | 37272.8 | 227898.7 | 4664.5–4007047.2 |
M6G/M (nmol/l) | 0.8 | 0.7 | 0.0–1.3 |
M3G/M (nmol/l) | 1.7 | 1.7 | 0.1–4.0 |
Day3 | |||
M (nmol/l) | 19625.9 | 122126.5 | 350.5–2695750.3 |
M6G (nmol/l) | 12568.8 | 56816.3 | 650.1–686950.1 |
M3G (nmol/l) | 32938.8 | 460521.7 | 2600.4–1372594.1 |
M6G/M (nmol/l) | 0.6 | 0.9 | 0.0–4.7 |
M3G/M (nmol/l) | 2.0 | 2.6 | 0.1–15.2 |