Table 2 Men with metastatic prostate cancer’s ratings of their QoL, functioning and symptoms (mean, SD, proportions) in relation to clinically relevant threshold values, as well as comparisons between groups based on time from last questionnaire to death p-values from One way ANOVA

Global health/QoL^a

70

56.0 (26.7)

189

70.1

38.5 (27.3)

40

87.5

55.7 (23.5)

64

75.0

64.5 (24.9)

85

59.3

< 0.001

Social functioning^a

66.8 (29.3)

187

50.4 (32.5)

38

66.4 (27.2)

63

74.4 (26.4)

86

< 0.001

Emotional functioning^a

70

72.9 (23.4)

188

43.6

59.5 (28.3)

39

67.5

73.6 (19.5)

63

46.9

78.5 (21.4)

86

29.0

< 0.001

Cognitive functioning^a

78.4 (22.8)

190

67.9 (27.1)

40

78.4 (22.7)

64

83.3 (19.0)

86

0.002

Physical functioning^a

83

72.9 (28.6)

187

54.5

54.2 (31.8)

38

75.0

71.7 (28.5)

64

56.3

82.2 (22.7)

85

42.4

< 0.001

Role functioning^a

60.2 (36.7)

173

36.7 (35.0)

34

57.4 (39.4)

61

72.6 (29.5)

78

< 0.001

Fatigue^b

39

39.2 (29.1)

189

38.6

62.1 (29.7)

39

70.0

39.9 (28.3)

64

40.6

28.2. (22.8)

86

22.1

< 0.001

Pain^b

25

31.8 (32.1)

190

49.5

53.8 (34.5)

40

77.5

29.4 (29.5)

64

50.0

23.3 (28.3)

86

36.0

< 0.001

Nausea /vomit^b

10.6 (17.3)

190

23.8 (23.2)

40

8.6 (15.4)

64

6.0 (11.7)

86

< 0.001

Dyspnoea^b

32.5 (29.5)

189

49.6 (34.9)

39

32.3 (27.2)

64

24.8 (25.1)

86

< 0.001

Insomnia^b

27.5 (28.7)

189

35.0 (29.2)

40

29.2 (29.4)

64

22.7 (27.3)

85

0.071

Constipation^b

17.8 (28.7)

187

34.2 (38.1)

40

14.3 (24.5)

63

12.7 (23.7)

84

0.001

Appetite loss^b

17.9 (27.4)

190

42.5 (32.9)

40

14.6 (24.4)

64

8.9 (18.7)

86

< 0.001

Diarrhoea^b

15.0 (24.2)

187

18.8 (27.4)

39

10.6 (20.6)

63

16.5 (25.0)

85

0.186

Urinary problems^c

2.8 (3.1)

184

3.7 (3.2)

38

2.4 (3.1)

63

2.6 (3.0)

83

0.082

Bowel problems^c

2.7 (2.7)

182

3.7 (2.9)

38

2.8 (2.8)

62

2.2 (2.5)

82

0.027

Sexual problems^c

6.9 (4.2)

173

7.0 (4.5)

36

7.5 (3.8)

58

6.3 (4.2)

79

0.219