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Table 4 Dose of midazolam according to prior medications

From: Midazolam sedation in palliative medicine: retrospective study in a French center for cancer control

CharacteristicsInduction dose (mg)Maintenance dose (mg/h)Dose at time of death (mg/h)
 NMedian
(range)
Mean
(sd)
p-valueNMedian
(range)
Mean
(sd)
p-valueNMedian
(range)
Mean
(sd)
p-value
Prior exposure to midazolam
 No (N = 17)81.5(0.5–3.0)1.6(1.1)0.004170.4(0.2–1.5)0.5(0.4)< 0.001161.0(0.2–8.0)1.8(2.0)0.003
 Yes (N = 37)183.8(1.0–10.0)4.9(3.2) 371.5(0.5–7.0)1.9(1.6) 373.0(0.6–24)4.4(4.9) 
Prior exposure to strong opioids
 No (N = 7)42.0(1.0–3.0)2.0(0.8)0.2270.6(0.2–1.5)0.8(0.4)0.3171.0(0.5–3.0)1.3(0.8)0.025
 Yes (N = 47)223.0(0.5–10)4.2(3.3) 471.0(0.2–7.0)1.6(1.6) 462.8(0.2–24)4.0(4.6) 
Prior exposure to medications
that impair alertness
 No (N = 33)153.0(0.5–10.0)3.8(3.2)0.81331.0(0.2–7.0)1.4(1.5)0.46332.0(0.2–9.0)2.7(2.4)0.18
 Yes (N = 21)113.0(0.5–10.0)3.9(3.2) 211.0(0.2–5.0)1.6(1.4) 202.8(0.5–24)5.1(6.3)