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Table 4 The improvement of oral symptom scores before and after oral care interventions in end-of-life patients with advanced cancers

From: Professional oral care in end-of-life patients with advanced cancers in a hospice ward: improvement of oral conditions

 

End-of-life patients (n = 27)

  

Oral care interventions

Pre-intervention

Post-intervention

Day 1

Day 4

Day 7

Cochran’s Q test

Friedman test

n (%)/ Median (IQR)

p

p

Oral conditions

 Mucosa healthiness

  Mucositis

   (+)

 

47.1%a

 

11.8%b

 

0.0%b

0.003*

 

   (−)

 

52.9%

 

88.2%

 

100.0%

  

  Candida infection

   (+)

 

68.8%a

 

37.5%b

 

43.8%

0.015*

 

   (−)

 

31.3%

 

62.5%

 

56.3%

  

  Oral bleeding

   (+)

 

17.6%

 

5.9%

 

0.0%

0.097

 

   (−)

 

82.4%

 

94.1%

 

100.0%

  

 Oral moisture

  Oral dryness

   SOD

 

41.2%

 

35.3%

 

29.4%

0.741

 

   NOD

 

58.8%

 

64.7%

 

70.6%

  

  Sensation of oral dryness

   (+)

 

63.6%a

 

27.3%

 

9.1%b

0.009*

 

   (−)

 

36.4%

 

72.7%

 

90.9%

  

 Oral cleanliness

  Oral debris

   Severe

 

52.9%a

 

5.9%b

 

11.8%b

0.001*

 

   Mild

 

47.1%

 

94.1%

 

88.2%

  

  Tongue coating index

0.3

(0.3–0.7)

0.3

(0.1–0.3)

0.2

(0.1–0.5)

 

0.065

General oral assessment

 OHAT at initial examination

  Total scores

7.0

(6.0–9.0)a

3.0

(1.0–4.0)b

2.0

(0.0–4.0)b

 

< 0.001*

   Lips

1.0

(1.0–2.0)a

0.0

(0.0–0.5)b

0.0

(0.0–0.0)b

 

< 0.001*

   Tongue

1.0

(1.0–1.5)a

1.0

(0.0–1.0)

1.0

(0.0–1.0)b

 

0.003*

   Gums and tissues

2.0

(1.5–2.0)a

1.0

(1.0–1.0)b

1.0

(1.0–1.0)b

 

< 0.001*

   Saliva

1.0

(1.0–2.0)a

1.0

(0.0–1.0)

1.0

(0.0–1.0)b

 

0.001*

   Natural teeth

1.0

(0.0–2.0)

1.0

(0.0–2.0)

1.0

(0.0–2.0)

 

1.000

   Dentures

0.0

(0.0–2.0)

0.0

(0.0–1.5)

0.0

(0.0–1.5)

 

0.368

   Oral cleanliness

1.0

(1.0–2.0)a

1.0

(0.0–1.0)

1.0

(0.0–1.0)b

 

0.002*

   Dental pain

0.0

(0.0–0.0)

0.0

(0.0–0.0)

0.0

(0.0–0.0)

 

0.368

Oral function

 Voice

  Abnormal

 

82.4%

 

76.5%

 

70.6%

0.549

 

  Normal

 

17.6%

 

23.5%

 

29.4%

  

 Swallow

  (+)

 

62.5%

 

81.3%

 

81.3%

0.165

 

  (−)

 

37.5%

 

18.8%

 

18.8%

  

 MMO

3.5

(2.5–4.0)

3.0

(2.0–3.8)

3.0

(3.0–3.5)

 

0.731

  1. Data are (%) or median (IQR)
  2. Abbreviations: IQR interquartile range, NOD Nonsevere Oral Dryness, SOD Severe Oral Dryness, OHAT Oral Health Assessment Tool, MMO Maximum Mouth Opening
  3. a, bDifferent upper case letters denote significant differences (p < 0.05) between groups by Cochran’s Q (asymptotic significances) / Friedman test (asymptotic significances) and their correspondent post hoc comparisons