Table 3 Sensitivity for meta-analysis based on QLQ-C30

 Mean (CI)

62.01 (57.72–66.29)

62.89 (56.78–69.00)

59.31 (55.62–63.00)

 Heterogeneity: Q

7.47, p = 0.02

17.77, p = 0.00

0.08, p = 0.78

 Heterogeneity: I²

69.60%

85.24%

0.00%

  Mean (CI)

23.61 (9.72–37.51)

23.70 (9.98–37.42)

30.27 (21.08–39.46)

  Heterogeneity: Q

45.47, p = 0.00

45.95, p = 0.00

2.97, p = 0.08

  Heterogeneity: I²

94.67%

94.70%

66.29%

  Mean (CI)

20.77 (15.49–26.05)

20.57 (14.79–26.36)

23.67 (19.15–28.18)

  Heterogeneity: Q

8.43, p = 0.01

10.33, p = 0.01

0.80, p = 0.37

 Heterogeneity: I²

73.89%

78.04%

0.00%

  Mean (CI)

16.20 (5.86–26.54)

19.09 (14.39–23-79)

21.57 (16.41–26.73)

  Heterogeneity: Q

47.50, p 0 0.00

7.02, p = 0.03

1.49, p = 0.22

  Heterogeneity: I²

94.23%

69.78%

33.00%

  Mean (CI)

17.97 (5.45–30.49)

18.23 (6.09–30.37)

22.64 (6.97–38.31)

  Heterogeneity: Q

41.63, p = 0.00

38.42, p = 0.00

15.25, p = 0.00

 Heterogeneity: I²

96.33%

96.15%

93.44%

  Mean (CI)

34.64 (19.96–49.33)

36.25 (24.57–47.92)

41.93 (33.65–50.21)

  Heterogeneity: Q

80.88, p = 0.00

49.73, p = 0.00

3.40, p = 0.07

  Heterogeneity: I²

96.65%

94.78%

70.62%

 Mean (CI)

30.81 (10.25–51.37)

31.15 (10.35–51.95)

27.22 (−6.34–60.77)

  Heterogeneity: Q

115.79, p = 0.00

122.74, p = 0.00

64.98, p = 0.00

  Heterogeneity: I²

98.39%

98.44%

98.46%

  Mean (CI)

15.51 (−0.39–31.41)

15.99 (0.73–31.25)

20.87 (−1.07–42.82)

  Heterogeneity: Q

41.26, p = 0.00

35.49, p = 0.00

22.28, p = 0.00

  Heterogeneity: I²

98.10%

97.99%

95.51%

  Mean (CI)

24.59 (19.89–29.29)

22.82 (14.39–31.24)

27.42 (23.52–31.31)

  Heterogeneity: Q

8.15, p = 0.02

32.50, p = 0.00

0.06, p = 0.81

  Heterogeneity: I²

71.76%

91.66%

0.00%

  Mean (CI)

33.27 (28.77–37.76)

32.93 (30.07–35.78)

30.25 (25.21–35.28)

  Heterogeneity: Q

4.28, p = 0.12

1.94, p = 0.38

0.18, p = 0.67

  Heterogeneity: I²

53.09%

17.20%

0.00%