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Table 2 Influencing Factors– Univariate Logistic Regression Analysis

From: Advance directives in patients with head and neck cancer - status quo and factors influencing their creation

Variable

N

OR

95% CI

Result of statistical analysis (p-value)

Gender (Female, n = 120)

446

 

 Male

326

1.081

[0.710–1.646]

0.717

Age group (> 75, n = 66)

446

   

  ≤ 30

6

0.000

[0.000–0.000]

.

 31–45*

22

0.059

[0.016–0.224]

< 0.001*

 46–65*

243

0.253

[0.139–0.461]

< 0.001*

 66–75*

109

0.426

[0.221–0.825]

0.011*

Marital status (Single, n = 55)

436

   

 Married*

298

4.221

[2.099–8.488]

< 0.001*

 Divorced*

13

3.000

[1.171–7.684]

0.022*

 Widowed*

35

3.778

[1.482–9.631]

0.005*

 Permanent partnership*

13

6.400

[1.748–23.438]

0.005*

Education level (Academic, n = 48)

243

1.155

[0.607–2.200]

0.661

At least one comorbidity (Yes)

401

2.372

[1.501–3.750]

0.001*

Cardiovascular comorbidity (Yes)

446

1.593

[1.087–2.334]

0.017*

Pulmonal comorbidity (Yes)

446

1.058

[0.620–1.804]

0.836

Neurological comorbidity (Yes)

446

1.232

[0.673–2.255]

0.500

Oncological comorbidity (Yes)

446

1.235

[0.790–1.931]

0.355

Regular medication (Yes)*

401

2.372

[1.501–3.750]

< 0.001*

Living environment (Living independent at home, n = 357)

411

 

 At home with support

49

1.172

[0.645–2.130]

0.603

 Care facility

5

0.281

[0.031–2.541]

0.259

Religion (Protestant, n = 182)

413

   

 Roman-catholic

173

0.752

[0.495–1.141]

0.181

 Muslim

5

0.000

[0.000–0.000]

0.999

 Other religion

27

0.744

[0.508–2.581]

0.744

 Atheist

26

0.672

[0.293–1.541]

0.348

Religiosity (Yes)

387

1.288

[0.577–2.876]

0.536

Cancer location (oral cavity & oropharynx, n = 147)

446

 

 Hypopharynx & larynx

116

1.069

[0.656–1.742]

0.789

 Nose & nasopharynx

34

0.760

[0.354–1.631]

0.481

 Salivary glands

61

1.446

[0.794–2.634]

0.227

 Other head and neck cancer entities

72

1.227

[0.686–2.159]

0.477

 Multi-tier carcinoma

16

0.558

[0.185–1.686]

0.301

Secondary malignanciesa (No, n = 360)

432

 

 Yes, synchronous

18

0.827

[0.321–2.133]

0.695

 Yes, metachronous

54

0.662

[0.372–1.177]

0.160

Recurrence of cancer (No, n = 395)

437

 

 Loco-regional recurrence

39

1.003

[0.519–1.941]

0.993

 Distant metastases

3

0.585

[0.053–6.506]

0.663

UICC stadium (Stadium IV, n = 119)

385

 

 0

6

0.492

[0.087–2.787]

0.423

 I

132

0.702

[0.426–1.157]

0.165

 II

67

0.797

[0.437–1.454]

0.460

 III

61

0.834

[0.449–1.549]

0.566

ECOG performance status (Stadium 0, n = 289)

386

 

 1

74

1.255

[0.753–2.093]

0.383

 2

21

2.973

[1.122–7.880]

0.028*

 3

2

1.189

[0.074–19.200]

0.903

Applied therapy (Surgery, n = 171)

446

 

 Primary surgery plus adjuvant therapy

198

1.168

[0.775–1.761]

0.497

 Definitive radiochemotherapy

71

0.823

[0.470–1.442]

0.457

 Salvage surgery

6

0.596

[0.106–3.342]

0.556

Time between initial diagnosis and survey period (120+ months, n = 63)

446

   

 0–12 months

113

1.104

[0.594–2.051]

0.754

 13–60 months

178

1.020

[0.572–1.819]

0.945

 61–120 months

92

1.250

[0.657–2.379]

0.497

  1. Reference categories: age group (> 75 years), marital status (single), educational level (non-academic) at least one comorbidity (no), cardiovascular comorbidity (no), Pulmonal comorbidity (no), neurological comorbidity (no), oncological comorbidity (no), regular medication (no), living environment (living independent at home), religion (Protestant), religiosity (no), Cancer location (oral cavity & oropharynx), secondary malignancy (no), recurrence of cancer (no), UICC stadium (IV), ECOG performance status (0), applied therapy (surgery), time between initial diagnosis and survey period (120+ months)
  2. Rows marked with an asterisk (*) indicate the influencing factors that were found to be statistically relevant
  3. N Number of patients, OR Odds ratio, 95% CI 95% confidence interval, p value of significance
  4. aAlso outside the head and neck area