Table 2 Comparison of characteristics of successful and unsuccessful methadone switching, N (%)
| Â | All patients | Successful switching | Unsuccessful switching |
|---|---|---|---|
Total | N = 90 | 64 (71.1) | 26 (28.9) |
Previously prescribed opioids | Â | Â | Â |
Extended-release oxycodone | 55 (61.1) | 41 (74.5) | 14 (15.5) |
Fentanyl transdermal patch | 9 (10.0) | 5 (55.5) | 4 (44.5) |
PCA* | 7 (7.8) | 6 (85.7) | 1 (14.3) |
Extended-release oxycodone or transdermal fentanyl combined with PCA | 18 (20.0) | 11 (61.1) | 7 (38.9) |
Extended-release oxycodone combined with fentanyl transdermal patch | 1 (1.1) | 1 (100.0) | 0 (0.0) |
Reasons for switching | Â | Â | Â |
Poor pain control | 67 (74.4) | 51 (76.1) | 16 (23.9) |
Intolerable adverse events | 9 (10.0) | 5 (55.6) | 4 (44.5) |
Both | 14 (15.6) | 8 (57.1) | 6 (42.9) |
Switching method | Â | Â | Â |
3-day switch | 50 (55.6) | 41 (82.0) | 9 (18.0) |
Stop and go | 40 (44.4) | 23 (57.5) | 17 (42.5) |
OMEDD pre-switching | Â | Â | Â |
< 300 mg | 40 (44.4) | 24 (60.0) | 16 (40.0) |
300–600 mg | 32 (35.6) | 26 (81.3) | 6 (18.8) |
> 600 mg | 18 (20.0) | 14 (77.8) | 4 (22.2) |
Conversion ratio | Â | Â | Â |
Under calculated ratio | 53 (58.9) | 39 (73.5) | 14 (26.4) |
Matched calculated ratio | 13 (14.4) | 9 (69.2) | 4 (30.8) |
Over calculated ratio | 24 (26.7) | 16 (66.7) | 8 (33.3) |