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Table 1 Core diagnostic criteria for cancer induced bone pain: ACTTION-APSa [14]

From: Methadone rotation versus other opioid rotation for refractory cancer induced bone pain: protocol of an exploratory randomised controlled open-label study

1. History of primary or metastatic bone cancer diagnosed using imaging and physical examination

2. Presence of continuous, background pain (usually described as annoying, dull, gnawing, aching, and/or nagging) in 1 or more locations generally consistent with known distribution of bone lesions

3. Presence of evoked or spontaneous pain (often described as electric or shock-like) in 1 or more locations generally consistent with known distribution of bone lesions, associated with weight bearing or movement or can occur spontaneously

4. Clinical examination over the site of pain reveals:

 • Hyperalgesia to blunt, non-noxious pressure or pin-prick stimuli

 • Hypoesthesia to non-noxious thermal stimuli

 • Hypoesthesia to light touch stimuli

  1. aAnalgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks-American Pain Society