Methadone rotation versus other opioid rotation for refractory cancer induced bone pain: protocol of an exploratory randomised controlled open-label study

Table 2 Measures used

	Eligibility	Baseline Day 0	Day 3	Day 5	Day 7	Day 10	Day 14
Hematology and Biochemistry screen (FBC/LFT/U&E)	×						x
ACTTION Criteria	×
ECG	×
*Reviews*
Clinical review—doctor	×
Clinical review—nurse		×	×	×	×	×	×
*Measures/Assessmens*
DN4		×
AKPS		×
EuroQOL		×			×		×
HADS		×			×		×
BAT		×			×		×
Daily BTP medication assessment		×	×	×	×	×	×
BPI		×			×		×
CTCAE		×	×	×	×	×	×
Worst Pain NRS		×	×	×	×	×	×
Average Pain NRS		×	×	×	×	×	×
Semi-structured interview				×

ACTTION Analgesic, anesthetic, and addiction clinical trial translations, innovations, opportunities, and networks American pain society, ECG Electrocardiogram, DN4 Douleur Neuropathique 4, AKPS Australian Karnofsky Performance Status, HADS Hospital Anxiety and Depression Scale, BAT Breakthrough Pain Assessment Tool, BTP Breakthrough pain, BPI Brief Pain Inventory, CTCAE Common Terminology Criteria for Adverse Events, NRS Numeric Rating Scale

ISSN: 1472-684X