Table 2 Change in ESAS items score median (IQR) from baseline to follow up

- Pain

5.0 (1.0, 8.0)

2.5 (0.0, 5.0)

 < 0.001

- Tiredness

5.0 (2.8, 8.0)

5.0 (2.0, 7.3)

0.187

- Drowsiness

0.0 (0.0, 5.0)

1.0 (0.0, 4.0)

0.574

- Nausea

0.0 (0.0, 1.0)

0.0 (0.0, 0.0)

0.239

- Loss of appetite

5.0 (1.0, 8.0)

4.0 (0.0, 6.0)

0.004

- Dyspnea

0.0 (0.0, 2.0)

0.0 (0.0, 1.3)

0.156

- Depression

2.0 (0.0, 5.0)

0.0 (0.0, 3.0)

 < 0.001

- Anxiety

1.5 (0.0, 3.0)

0.0 (0.0, 3.0)

0.032

- Well-being

0.5 (0.0, 5.0)

1.0 (0.0, 4.0)

0.171

- Total ESAS Score

25.5 (16.0, 35.0)

20 (12.8, 27.0)

 < 0.001